AFFERENT AND EFFERENT CONNECTIONS OF THE A5 NORADRENERGIC CELL GROUP IN THE RAT
AFFERENT AND EFFERENT CONNECTIONS OF THE A5 NORADRENERGIC CELL GROUP IN THE RAT
复制标题
DOI：
10.1002/cne.902610406
复制
发表时间：
1987-07-22
影响因子：
2.5
通讯作者：
GUYENET, PG
中科院分区：
文献类型：
--
作者：
BYRUM, CE;GUYENET, PG
在大鼠脊髓上观察了A5去甲肾上腺素能细胞群的传入和传出联系。在A5区的喙部发现了非常小的HRP-WGA沉积物。用儿茶酚胺组织荧光技术证实沉积物与A5柱重叠。逆行标记细胞分布于下丘脑穹窿周围区、室旁核、Kolliker-Ehrman核、臂旁背侧区、孤束核的中间部和尾侧部以及延髓腹侧网状结构的A1和B1细胞群区域。顺行HRP-WGA标记被发现在几个地区的皮质下中枢神经系统。A5神经元的贡献，这种标记证实了逆行运输荧光乳胶微球结合儿茶酚胺组织荧光技术。A5细胞群向杏仁核中央核、下丘脑穹窿周围区、中脑导水管周围灰质、臂旁区和孤束核有明显的投射。其他的A5投射包括丘脑的室旁核、终纹的床核，可能还有下丘脑的前角区、外侧区和背侧区。此外，A5神经元可能支配延髓腹外侧网状结构。几乎所有由A5去甲肾上腺素能神经元支配的区域都参与心血管调节。此外，A5区接收来自脊髓上中枢神经系统主要心血管调节中心的传入输入。因此，A5细胞群具有对心血管调节系统施加显著影响的潜力。
The supraspinal afferent and efferent connections of the A5 noradrenergic cell group were examined in rats. Very small deposits of HRP-WGA were made in the rostral A5 area. Catecholamine histofluorescence techniques were used to confirm that the deposits overlapped the A5 column. Retrogradely labeled cells were present in the perifornical area and paraventricular nucleus of the hypothalamus, the Kolliker-Fuse nucleus, dorsal parabrachial area, intermediate and caudal portions of the nucleus of the solitary tract, and the ventral medullary reticular formation in the areas of the A1 and B1 cell groups. Anterograde HRP-WGA labeling was found in several areas of the subcortical CNS. The contribution of A5 neurons to this labeling was confirmed with retrogradely transported fluoresent latex microspheres combined with catecholamine histofluorescence techniques. The A5 cell group was found to have significant projections to the central nucleus of the amygdala, perifornical area of the hypothalamus, midbrain periaqueductal gray, parabrachial area, and the nucleus of the solitary tract. Other A5 projections include the paraventricular nucleus of the thalamus, the bed nucleus of the stria terminalis, and possibly the zona incerta and lateral and dorsal hypothalamic areas. In addition, A5 neurons may innervate the ventrolateral reticular formation of the medulla. Virtually all of the areas innervated by A5 noradrenergic neurons are involved in cardiovascular regulation. In addition, the A5 area receives afferent input from major cardiovascular regulatory centers of the supraspinal CNS. Thus the A5 cell group has the potential to exert a significant influence on the cardiovascular regulatory system.