The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization.
The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization.
复制标题
果蝇幼虫对黄蜂寄生的细胞免疫反应需要伤害感受基因 painless 和 Piezo。
DOI：
10.1016/j.bbrc.2017.03.116
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发表时间：
2017
影响因子：
3.1
通讯作者：
Schulz,RobertA
中科院分区：
文献类型：
--
作者：
Tokusumi,Yumiko;Tokusumi,Tsuyoshi;Schulz,RobertA
在脊椎动物中，神经系统和免疫系统之间的相互作用对于保护受挑战的宿主免受外部来源的压力输入非常重要。在这项研究中，我们证明感觉神经元参与果蝇幼虫黄蜂感染引起的细胞免疫反应。多树突 IV 类神经元感知来自外部刺激的接触并诱导宿主防御的回避行为。我们的研究结果表明，这些感觉神经元的失活会损害细胞对黄蜂寄生的反应。我们还证明，编码机械感觉受体 Painless 和 Piezo 的伤害感受基因（均在 IV 类神经元中表达）对于对寄生虫攻击的正常细胞免疫反应至关重要。
In vertebrates, interaction between the nervous system and immune system is important to protect a challenged host from stress inputs from external sources. In this study, we demonstrate that sensory neurons are involved in the cellular immune response elicited by wasp infestation ofDrosophilalarvae. Multidendritic class IV neurons sense contacts from external stimuli and induce avoidance behaviors for host defense. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization. We also demonstrate that the nociception genes encoding the mechanosensory receptors Painless and Piezo, both expressed in class IV neurons, are essential for the normal cellular immune response to parasite challenge.