Redesigning nature's poisons to create anti-tumor reagents.
Redesigning nature's poisons to create anti-tumor reagents.
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DOI：
10.1126/science.3317828
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发表时间：
1987-11
期刊：
影响因子：
56.9
通讯作者：
E. Vitetta;R. Fulton;R. May;M. Till;J. Uhr
中科院分区：
文献类型：
--
作者：
E. Vitetta;R. Fulton;R. May;M. Till;J. Uhr
免疫毒素是细胞反应性抗体和毒素或其亚基的结合物。在本报告中，第一代免疫毒素的化学、生物学、药代动力学和抗肿瘤作用；具有更强抗肿瘤作用的改良第二代免疫毒素的制备；并讨论了基因工程在制造第三代免疫毒素中的作用。
Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.