The effect of exercise on plasma somatomedin-C/insulinlike growth factor I concentrations.
The effect of exercise on plasma somatomedin-C/insulinlike growth factor I concentrations.
复制标题
运动对血浆生长调节素-C/胰岛素样生长因子 I 浓度的影响。
DOI：
10.1016/0026-0495(87)90162-4
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
McMurray,R
中科院分区：
文献类型：
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作者：
Smith,AT;Clemmons,DR;Underwood,LE;Ben-Ezra,V;McMurray,R
由于能量或蛋白质摄入不足会导致血浆中生长抑素-C/胰岛素样生长因子-I(Sm-C IGF-I)浓度的降低，我们已经完成了一项研究，以确定持续一周的剧烈运动导致的能量不足是否也与这种多肽的减少有关。当6名健康、有运动条件的男性在7天运动期的最后两天中，以35千卡/千克理想体重(IBW)和1.0g蛋白质/千克的饮食和每天消耗14.1~16.3千卡能量的运动，其血浆Sm-C IGF-I浓度从平均基础值1.15±0.78(1±SD)降至0.62±0.41U/mL(P<；05)。Sm-C-IFG-I的这种下降几乎完全发生在研究期间的前四天。在驯化3周后，每个志愿者的卡路里摄入量减少了与运动周中每天运动消耗的卡路里相同的卡路里数量(平均为15.1kcal/kg IBW/d)。在该方案中，Sm-C、IGF-I的平均血浆浓度从1.12±0.57U/mL降至最后两天的0.69±0.37U/mL。限制饮食的跌倒幅度与运动时观察到的没有显著差异。运动期后3天的日均氮平衡为−1.60±1.70g/d，而限食后3天的日均氮平衡为−3.50±1.73g/d(P<；05)。在运动期间，氮的最大损失发生在本周早些时候，与Sm-C IGF-I的下降平行。然而，在饮食限制期间，没有保存氮的趋势。这些结果表明，产生负热量平衡的剧烈运动会导致Sm-C IGF-I下降，与没有运动的等量热量限制一样多。运动中的氮平衡负值较小，这表明这种运动有节氮的效果。
Because inadequate intake of energy or protein causes reduction in the plasma concentrations of somatomedin-C/insulinlike growth factor I (Sm-C IGF-I), we have completed studies to determine whether the energy deficit induced by vigorous exercise sustained for 1 week would also be associated with a reduction in this peptide. When six healthy, exercise-conditioned males were fed a diet consisting of 35 kcal/kg ideal body weight (IBW) and 1.0 g protein/kg and exercised so that 14.1 to 16.3 kcal/kg of energy was expended each day, their plasma Sm-C IGF-I concentrations declined from a mean basal value of 1.15±0.78 U/mL (1±SD) to 0.62±0.41 U/mL during the last two days of a seven-day exercise period (P<. 05). This decrease in Sm-C IFG-I occurred almost entirely in the first four days of the study period. After 3 weeks for reacclimation, the calorie intake of each volunteer was reduced by the same number of calories as had been expended in the form of exercise during each day of the exercise week (mean of 15.1 kcal/kg IBW/d). On this regimen the mean plasma Sm-C IGF-I declined from 1.12±0.57 U/mL, to 0.69±0.37 U/mL on the last two days of dietary restriction. The magnitude of fall with dietary restriction was not significantly different from that observed during exercise. During the last three days of the exercise period the mean daily nitrogen balance was− 1.60±1.70 g/d, while this value was− 3.50±1.73 g/d during the last three days of dietary restriction (P<. 05). During exercise the greatest loss of nitrogen occurred early in the week, in parallel with the decline in Sm-C IGF-I. During dietary restriction, however, there was no trend toward conservation of nitrogen. These results show that strenuous exercise that produces negative caloric balance causes Sm-C IGF-I to fall as much as equivalent caloric restriction without exercise. The less negative nitrogen balance with exercise suggests that such exercise has a nitrogen-sparing effect.