Development of multiple-layer polymeric particles for targeted and controlled drug delivery.
Development of multiple-layer polymeric particles for targeted and controlled drug delivery.
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DOI：
10.1016/j.nano.2009.07.008
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发表时间：
2010-04
影响因子：
5.4
通讯作者：
Nguyen, Kytai Truong
中科院分区：
文献类型：
--
作者：
Koppolu, Bhanuprasanth;Rahimi, Maham;Nattama, Sivaniarvindpriya;Wadajkar, Aniket;Nguyen, Kytai Truong
本工作的目的是开发由一个磁核和两个由聚(N-异丙基丙烯酰胺)(PNIPAAm)和聚(d，L-丙交酯-乙交酯)(PLGA)组成的包覆壳的多层微球，用于靶向和控制给药。透射电子显微镜证实，PNIPAAm磁性纳米粒子嵌入在PLGA壳层中，得到了多层粒子。析因分析研究还表明，颗粒大小与表面活性剂浓度和超声功率成反比，与PLGA浓度成正比。药物释放结果表明，这些多层微粒分别产生了牛血清白蛋白(BSA)和姜黄素的初始突发释放和随后的持续释放。BSA的释放也受到温度变化的影响。综上所述，我们的结果表明，可以合成多层磁性颗粒，并将其用于多种不同释放机制的药物的靶向和控制释放。
The purpose of this work was to develop multilayered particles consisting of a magnetic core and two encompassing shells made up of poly (N-isopropylacrylamide) (PNIPAAm) and poly(d,l-lactide-co-glycolide) (PLGA) for targeted and controlled drug delivery. Transmission electron microscopy confirmed that multilayered particles were obtained with PNIPAAm magnetic nanoparticles embedded within the PLGA shell. Factorial analysis studies also showed that the particle size was inversely proportional to the surfactant concentration and sonication power and directly proportional to the PLGA concentration. Drug-release results demonstrated that these multilayer particles produced an initial burst release and a subsequent sustained release of both bovine serum albumin (BSA) and curcumin loaded into the core and shell of the particle, respectively. BSA release was also affected by changes in temperature. In conclusion, our results indicate that the multilayered magnetic particles could be synthesized and used for targeted and controlled delivery of multiple drugs with different release mechanisms.
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