Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia.
Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia.
复制标题
嗜酸性粒细胞性肺炎患者支气管肺泡灌洗液中骨膜蛋白浓度升高。
DOI：
10.1159/000494623
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Nagata M.
中科院分区：
文献类型：
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作者：
Nakagome K;Nakamura Y;Kobayashi T;Ohta S;Ono J;Kobayashi K;Ikebuchi K;Noguchi T;Soma T;Yamauchi K;Izuhara K;Nagata M.
研究背景嗜酸性粒细胞性肺炎（Eosinophilic pneumonia，EP）是一种以嗜酸性粒细胞大量浸润为特征的肺部疾病.虽然血清骨膜蛋白是嗜酸性粒细胞为主的哮喘的一个新的标志物，但骨膜蛋白在哮喘患者气道中的上调是有争议的。在这项研究中，我们研究了骨膜蛋白浓度是否升高的支气管肺泡灌洗液（BALF）的患者EP。MethodsBAL进行健康志愿者和急性嗜酸性粒细胞性肺炎（AEP），慢性嗜酸性粒细胞性肺炎（CEP），结节病患者。BALF中的骨膜蛋白浓度measured.ResultsThe骨膜蛋白浓度在BALF中的肺嗜酸性粒细胞增多显着增加，并高于AEP和CEP患者比健康志愿者和结节病患者，即使在调整白蛋白浓度。在嗜酸性粒细胞增多症中，骨膜蛋白浓度与嗜酸性粒细胞计数、淋巴细胞计数、白蛋白浓度以及IL-5、IL-13、转化生长因子β 1等细胞因子浓度相关。结论虽然EP患者BALF中骨膜蛋白浓度升高可能与部分漏血有关，但骨膜蛋白至少部分是由局部诱导产生的。因此，骨膜蛋白可能在EP的发生发展中发挥作用。
BackgroundEosinophilic pneumonia (EP) is characterized by massive pulmonary infiltration by eosinophils. Although serum periostin is a novel marker for eosinophil-dominant asthma, the upregulation of periostin in the airway of asthmatics is controversial. In this study, we examined whether periostin concentrations are elevated in the bronchoalveolar lavage fluid (BALF) of patients with EP.MethodsBAL was performed in healthy volunteers and in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), and sarcoidosis. The periostin concentrations in the BALF were measured.ResultsThe periostin concentration in the BALF increased significantly with pulmonary eosinophil ia and was higher in AEP and CEP patients than in healthy volunteers and sarcoidosis patients, even after adjusting the albumin concentration. In pulmonary eosinophilia, the periostin concentration correlated with the eosinophil and lymphocyte counts, the concentration of albumin, and the concentration of cytokines such as IL-5, IL-13, and transforming growth factor β1.ConclusionsAlthough some blood leakage may be involved in the elevation of periostin in the BALF of EP, periostin can be induced locally, at least in part. Therefore, periostin may play a role in the development of EP.