Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells
Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells
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DOI：
10.1016/j.febslet.2014.06.018
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发表时间：
2014-08-25
期刊：
影响因子：
3.5
通讯作者：
Zhang, Bo
中科院分区：
文献类型：
--
作者：
Jia, Xinying;Zhang, Hong;Zhang, Bo
气道上皮暴露于环境中的一系列刺激物，已知这些刺激物会引发炎症反应，如哮喘。瞬时受体电位香草素1（TRPV 1）是一种Ca 2+渗透性阳离子通道，对于检测感觉神经元的伤害性刺激至关重要。近年来，越来越多的证据表明TRPV 1在人类气道上皮中也参与了哮喘的病理生理过程。在这里，我们报告说，在气道上皮细胞中，TRPV 1的激活有效地诱导过敏性细胞因子胸腺基质淋巴细胞生成素（TSLP）的释放。蛋白酶激活受体（PAR）-2激活的TSLP诱导也部分由TRPV 1通道介导。(C)2014年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
The airway epithelium is exposed to a range of irritants in the environment that are known to trigger inflammatory response such as asthma. Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable cation channel critical for detecting noxious stimuli by sensory neurons. Recently increasing evidence suggests TRPV1 is also crucially involved in the pathophysiology of asthma on airway epithelium in human. Here we report that in airway epithelial cells TRPV1 activation potently induces allergic cytokine thymic stromal lymphopoietin (TSLP) release. TSLP induction by protease-activated receptor (PAR)-2 activation is also partially mediated by TRPV1 channels. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.