Association of Central Auditory Processing Dysfunction With Preclinical Alzheimer's Disease.
Association of Central Auditory Processing Dysfunction With Preclinical Alzheimer's Disease.
复制标题
中枢听觉处理功能障碍与临床前阿尔茨海默病的关联。
DOI：
10.1002/ohn.228
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
KBASEResearchGroup
中科院分区：
文献类型：
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作者：
Byun,MinSoo;Chang,Munyoung;Yi,Dahyun;Ahn,Hyejin;Han,Dongkyun;Jeon,Seulki;Jang,Hyunsook;Lee,DongYoung;Oh,SeungHa;KBASEResearchGroup
目的探讨临床前阿尔茨海默病（AD）患者中是否存在大脑β-淀粉样蛋白（Aβ）阳性的认知正常（CN）老年人的中枢听觉处理功能障碍（DDT 1）沉积和探索DDT 1作为临床前AD筛查试验的潜力。研究设计横断面设计。设置前瞻性观察性队列研究。方法CN老年人包括具有总体临床痴呆评定分数为0的成人。听力测试电池，包括纯音测听，言语测听，畸变产物耳声发射，和DDT1.ResultsFifty CN老年人被纳入。其中Aβ沉积阴性（AN）组38例，Aβ沉积阳性（AP）组12例。AP组较好耳和较差耳的DDT 1评分均显著低于AN组（分别为p= 0.008和p = 0.015）。在外周听觉通路的测试中，两组之间没有观察到显著差异。在调整载脂蛋白E4阳性的多变量logistic回归分析中，DDT 1更好的耳评分预测AP组（p= 0.036，比值比= 0.892，95%置信区间：0.780 - 0.985），具有相对较高的诊断准确性。DDT 1可以很容易地应用于老年人群，可能有潜力作为临床前AD的筛查工具。
ObjectiveTo investigate whether central auditory processing dysfunction measured by the dichotic digit test‐1 digit (DDT1) is present in preclinical Alzheimer's disease (AD) individuals who are cognitively normal (CN) older adults with the cerebral beta‐amyloid (Aβ) deposition and to explore the potential of the DDT1 as a screening test for preclinical AD.Study DesignCross‐sectional design.SettingA prospective observational cohort study.MethodsCN older adults with a global clinical dementia rating score of 0 were included. The hearing test battery including pure‐tone audiometry, speech audiometry, distortion product otoacoustic emission, and DDT1 was administered to participants.ResultsFifty CN older adults were included. Among them, 38 individuals were included in the Aβ deposition negative (AN) group and 12 were included in the Aβ deposition positive (AP) group. The DDT1 scores of both the better and worse ears were significantly lower in the AP group than in the AN group (p= .008 andp= .015, respectively). No significant differences were observed between the groups in tests of the peripheral auditory pathways. In multivariable logistic regression analysis adjusted for apolipoprotein E4 positivity, the DDT1 better ear score predicted the AP group (p= .036, odds ratio = 0.892, 95% confidence interval: 0.780‐0.985) with relatively high diagnostic accuracy.ConclusionOur findings suggest that Aβ deposition may affect the central auditory pathway even before cognitive decline appears. DDT1, which can easily be applied to the old‐age population, may have the potential as a screening tool for preclinical AD.