Cytological characteristics of invasive lobular carcinoma of the human breast
Cytological characteristics of invasive lobular carcinoma of the human breast
复制标题
人乳腺浸润性小叶癌的细胞学特征
DOI：
10.1007/s00795-008-0408-9
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发表时间：
2008
影响因子：
1.8
通讯作者：
S. Tsuchiya
中科院分区：
文献类型：
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作者：
S. Tsuchiya
与浸润性导管癌不同，乳腺浸润性小叶癌（ILC）的特征是同侧多发，对侧乳腺的发病率较高。因此，有必要彻底检查是否有任何其他癌症存在之前，任何保乳手术进行。我们从细胞学、组织学和超微结构上研究了ILC和纯硬癌（PSC）（浸润性导管癌的一种亚型），以建立这两种具有高度组织学相似性的癌的鉴别诊断的细胞学诊断标准。细胞学上，ILC细胞呈线状或孤立排列，核小，染色质呈均匀分布的细颗粒状。细胞质颜色浅，单个细胞缺乏凝聚力。癌细胞呈玫瑰花状。PSC细胞呈线状或索状排列。单个细胞呈垂直排列。PSC细胞具有线性胞质边缘，其特征在于具有粗颗粒染色质的核模塑。这些细胞学结果得到了组织学和超微结构结果的支持。这些发现可能有助于术前细胞学诊断ILC的组织学评估。
In contrast to invasive ductal carcinoma, invasive lobular carcinoma (ILC) of the breast is characterized by multiple ipsilateral occurrences and a higher incidence in the contralateral breast. It is therefore necessary to examine thoroughly whether there is any other carcinoma present before any breast-conserving surgery is carried out. We cytologically, histologically, and ultrastructurally investigated ILC and pure scirrhous carcinoma (PSC), a subtype of invasive ductal carcinoma, to establish cytological diagnostic criteria for the differential diagnosis of these two types of carcinoma that have high histological similarity. Cytologically, ILC cells showed linear or isolated cell arrangements and had small nuclei with round homogeneously distributed fine granular chromatin. The cytoplasm was light, and individual cells lacked cohesion. The carcinoma showed a rosary-like configuration. PSC cells, however, showed linear or cordlike arrangements. Individual cells showed a vertical arrangement. PSC cells had a linear cytoplasmic edge and were characterized by nuclear molding with coarse granular chromatin. These cytological findings were supported by histological and ultrastructural findings. These findings may contribute to histological estimation of ILC in preoperative cytological diagnosis.