Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
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DOI：
10.1016/s1074-7613(00)80219-8
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发表时间：
2000-06-01
期刊：
影响因子：
32.4
通讯作者：
Parham, P
中科院分区：
文献类型：
--
作者：
Khakoo, SI;Rajalingam, R;Parham, P
NK细胞受体与快速进化的MHC-I类配体结合，表明它们也进化得很快。为了验证这一假设，我们测定了黑猩猩KIR和CD94：NKG2受体的结构和I类特异性，并与它们的人类受体进行了比较。KIR家族是不同的，只有三个KIR在黑猩猩和人类之间保守。相比之下，CD94：NKG2受体是保守的。多态I类的受体是分化的，非多态I类的受体是保守的。尽管黑猩猩和人类NK细胞对MHC-C表现出相同的受体特异性，但它们是由非同源KIR介导的。这些结果证明了NK细胞受体系统的快速进化，并暗示“赶上”第I类并不是推动这一进化的唯一力量。
That NK cell receptors engage fast-evolving MHC class I ligands suggests that they, too, evolve rapidly. To test this hypothesis, the structure and class I specificity of chimpanzee KIR and CD94:NKG2 receptors were determined and compared to their human counterparts. The KIR families are divergent, with only three KIR conserved between chimpanzees and humans. By contrast, CD94:NKG2 receptors are conserved. Whereas receptors for polymorphic class I are divergent, those for nonpolymorphic class I are conserved. Although chimpanzee and human NK cells exhibit identical receptor specificities for MHC-C, they are mediated by nonorthologous KIR. These results demonstrate the rapid evolution of NK cell receptor systems and imply that "catching up" with class I is not the only force driving this evolution.