Colorectal cancer risks in relatives of young-onset cases: Is risk the same across all first-degree relatives?
Colorectal cancer risks in relatives of young-onset cases: Is risk the same across all first-degree relatives?
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DOI：
10.1016/j.cgh.2007.06.001
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发表时间：
2007-10-01
影响因子：
12.6
通讯作者：
Gallinger, Steven
中科院分区：
文献类型：
--
作者：
Boardman, Lisa A.;Morlan, Bruce W.;Gallinger, Steven
背景与目的：在过去的15年中，已经发现了几种单基因孟德尔疾病，这些疾病可能解释了在大肠癌人群研究中发现的一些家族聚集性疾病。癌症(CRC)。DNA错配修复（MMR）基因突变导致遗传性非息肉病性结直肠癌- lynch综合征，这是公认的最常见的crc易感综合征，其一个主要特征是癌症发病年龄小。然而，对于年轻发病的微卫星稳定型（MSS） CRC，其家族性风险尚不清楚。方法：对结直肠癌患者
Background & Aims: During the last 15 years, several single-gene mendelian disorders have been discovered that might account for some of the familial aggregation detected in large population studies of colorectal. cancer (CRC). Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer-Lynch syndrome, the most common of the recognized CRC-predisposition syndromes, in which one major feature is a young age for cancer onset. However, for young-onset microsatellite stable (MSS) CRC, the familial risk for CRC is unknown. Methods: Patients with CRC who were