Annexin A3-Expressing Cellular Phenotypes Emerge from Necrotic Lesion in the Pericentral Area in 2-Acetylaminofluoren/Carbon Tetrachloride-Treated Rat Livers
Annexin A3-Expressing Cellular Phenotypes Emerge from Necrotic Lesion in the Pericentral Area in 2-Acetylaminofluoren/Carbon Tetrachloride-Treated Rat Livers
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2-乙酰氨基芴/四氯化碳处理的大鼠肝脏中央区域坏死病灶出现膜联蛋白 A3 表达细胞表型
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
T. Ariga
中科院分区：
文献类型：
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作者：
Yoshimasa Ito;Takenori Watanabe;Shunsuke Nagatomo;T. Seki;S. Niimi;T. Ariga
最近，我们发现了一个小的肝细胞特异性蛋白，膜联蛋白A3（AnxA 3），在成年大鼠肝细胞分级。在这里，我们描述了在体内演示的AnxA 3表达细胞表型在肝脏与2-乙酰氨基芴（2-AAF）/四氯化碳（CCl 4）损伤的结果。与丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）活性的升高相关，肝脏AnxA 3 mRNA表达显著增加。AnxA 3阳性细胞检测到集群细胞存在于或新兴的中央周围区。这些表达白蛋白的细胞在组织学上与表达CD 34（一种造血细胞标记蛋白）的细胞相似。在CCl 4处理后的几天内，簇的数量减少，出现膜联蛋白阴性，但白蛋白阳性的卵圆形细胞。我们的结论是，药物诱导的肝缺损最初招募骨髓源性细胞，并促进这些细胞分化为AnxA 3阳性细胞，随后出现卵圆细胞，这可能在受损肝脏的恢复中发挥作用。
Recently we found a small hepatocyte-specific protein, annexin A3 (AnxA3), in fractionated adult rat hepatocytes. Here we describe the results of an in vivo demonstration of AnxA3-expressing cellular phenotypes in the liver with 2-acetylaminofluoren (2-AAF)/carbon tetrachloride (CCl4)-injury. In association with an elevation of alanine amino transferase (ALT) and aspartic acid amino transferase (AST) activities, hepatic AnxA3 mRNA increased markedly. AnxA3-positive cells were detected in clustered cells present in or emerging from the pericentral region. These albumin-expressed cells were histologically similar to cells expressing CD34, a hematopoietic cell marker protein. The number of clusters decreased in the days following CCl4 treatment, and annexin-negative, but albumin-positive, oval cells appeared. We concluded that the agent-induced liver defect initially recruits bone marrow-derived cells, and that it promotes differentiation of these cells into AnxA3-positive cells, followed by emergence of the oval cells, which might have a role in the restitution of the damaged liver.
钙依赖性中性粒细胞分泌：膜联蛋白的表征和调节。
DOI：
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发表时间：
1997
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Rosales,JL;Ernst,JD
通讯作者：
Ernst,JD
胆管结扎和随后的四氯化碳 3 区坏死后大鼠肝脏中导管肝细胞的外观。
DOI：
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发表时间：
1992
期刊：
The American journal of pathology
影响因子：
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作者：
Sirica,AE;Williams,TW
通讯作者：
Williams,TW