Mapping the Perceptual Grain of the Human Retina
Mapping the Perceptual Grain of the Human Retina
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DOI：
10.1523/jneurosci.5191-13.2014
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发表时间：
2014-04-16
影响因子：
5.3
通讯作者：
Sincich, Lawrence C.
中科院分区：
文献类型：
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作者：
Harmening, Wolf M.;Tuten, William S.;Sincich, Lawrence C.
在人类中，很难实现对单一感觉受体的实验性接触，但这对于了解每个受体产生的信号如何转化为感知至关重要。通过结合自适应光学微刺激与高速眼动跟踪，我们表明，视网膜功能可以探测在活体眼睛中的个体视锥细胞的水平。经典的心理测量功能，从锥形大小的微刺激针对单一的光感受器。从心理学的角度来看，锥状马赛克还表现出对整个表面的光的可变敏感性，这符合锥状光捕获的简单模型。由于这种微观的视觉颗粒可以在感知层面上被检测到，这表明如果眼睛光学系统对光线的正常次优中继被纠正，光感受器可以单独作用以形成感知。因此，视锥细胞的精确排列和刺激物在这些视锥细胞上的精确放置产生了对介导空间视觉的信号的初始视网膜限制。
In humans, experimental access to single sensory receptors is difficult to achieve, yet it is crucial for learning how the signals arising from each receptor are transformed into perception. By combining adaptive optics microstimulation with high-speed eye tracking, we show that retinal function can be probed at the level of the individual cone photoreceptor in living eyes. Classical psychometric functions were obtained from cone-sized microstimuli targeted to single photoreceptors. Revealed psychophysically, the cone mosaic also manifests a variable sensitivity to light across its surface that accords with a simple model of cone light capture. Because this microscopic grain of vision could be detected on the perceptual level, it suggests that photoreceptors can act individually to shape perception, if the normally suboptimal relay of light by the eye's optics is corrected. Thus the precise arrangement of cones and the exact placement of stimuli onto those cones create the initial retinal limits on signals mediating spatial vision.