Patients With Scans Without Evidence of Dopaminergic Deficit: A Long-Term Follow-up Study
Patients With Scans Without Evidence of Dopaminergic Deficit: A Long-Term Follow-up Study
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DOI：
10.1002/mds.26018
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发表时间：
2014-12-01
影响因子：
8.6
通讯作者：
Bhatia, Kailash P.
中科院分区：
文献类型：
--
作者：
Batla, Amit;Erro, Roberto;Bhatia, Kailash P.
背景：我们之前报道了一组肌张力障碍震颤和扫描没有多巴胺能缺陷(SWEDDS)证据的患者。我们的目标是报告这些患者的长期临床和影像随访。患者和方法：包括至少5年随访的患者。这些患者有不对称的手臂震颤，先前诊断为帕金森氏病(PD)，随后进行了正常的DAT扫描。在临床基础上进行影像和临床随访。结果：纳入16例患者。第一次扫描和后续扫描之间的平均间隔为5.4年。2名患者(12.5%)在随访的DAT扫描中黑质纹状体摄取减少，而14名患者仍有正常的多巴胺能成像。结论：这是迄今为止报道的非对称性静息性震颤和正常DAT扫描(SWEDD)患者的最长随访时间。我们在这里显示，在长期的随访中，只有少数患者表现出纹状体黑质摄取的减少。(C)2014年国际帕金森病和运动障碍协会
Background: We previously reported on a cohort of dystonic tremor and patients with scans without evidence of dopaminergic deficit (SWEDDs). We aim to report the long-term clinical and imaging follow-up of these patients.Patients and Methods: Patients with at least 5-year follow-up were included. These patients had an asymmetric arm tremor, a previous diagnosis of Parkinson's disease (PD), and a subsequent normal DaTscan. The imaging and clinical follow-up was done on the clinical basis.Results: Sixteen patients were included. The mean gap between the first and subsequent scans was 5.4 years. Two patients (12.5%) had reduced nigrostriatal uptake on follow-up DaTscan, whereas 14 continued to have normal dopaminergic imaging.Conclusion: This is the longest follow up of patients with asymmetric rest tremor and normal DaT scans (SWEDDs) reported to date. We show here that only a minority of them show reduced striatonigral uptake over long term follow up. (C) 2014 International Parkinson and Movement Disorder Society