Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.
Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.
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DOI：
10.1016/j.celrep.2015.09.064
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发表时间：
2015-11-10
期刊：
影响因子：
8.8
通讯作者：
Lai HC
中科院分区：
文献类型：
--
作者：
Yuengert R;Hori K;Kibodeaux EE;McClellan JX;Morales JE;Huang TP;Neul JL;Lai HC
本体感觉，即肢体和身体位置的感觉，对于产生适当的运动是必不可少的。无意识的本体感觉信息通过脊髓和延髓中的小脑投射神经元传递。由碱性螺旋-环-螺旋(BHLH)转录因子Atoh1定义的前体结构域参与了这些小脑投射神经元的形成；然而，它们对本体感觉束和运动行为的确切贡献尚不清楚。值得注意的是，我们证明脊髓中的Atoh1类神经元存在于Clarke柱(CC)之外，CC是传递后肢本体感觉的神经元的主要贡献者，尽管在延髓外楔状核(ECU)中引起了CC的解剖和功能相关，后者介导了前肢本体感觉。消除尾侧Atoh1谱系会导致小鼠相对正常的运动，但无法执行协调的运动任务。总而言之，我们揭示了脊髓和延髓中的本体感觉核来自不止一个祖细胞来源，这暗示了一种揭示不同本体感觉功能的途径。
Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinal cord and medulla. The progenitor domain defined by the basic helix-loop-helix (bHLH) transcription factor, ATOH1, has been implicated in forming these cerebellar-projecting neurons; however, their precise contribution to proprioceptive tracts and motor behavior is unknown. Significantly, we demonstrate that Atoh1-lineage neurons in the spinal cord reside outside Clarke’s column (CC), a main contributor of neurons relaying hindlimb proprioception, despite giving rise to the anatomical and functional correlate of CC in the medulla, the external cuneate nucleus (ECu), which mediates forelimb proprioception. Elimination of caudal Atoh1-lineages results in mice with relatively normal locomotion, but unable to perform coordinated motor tasks. Altogether, we reveal that proprioceptive nuclei in the spinal cord and medulla develop from more than one progenitor source suggesting an avenue to uncover distinct proprioceptive functions.