Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery
Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery
复制标题
生物矿化启发纳米载体表面工程，用于 pH 响应、靶向药物输送
DOI：
10.1016/j.biomaterials.2012.10.060
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发表时间：
2013-01-01
期刊：
影响因子：
14
通讯作者：
Qu, Xiaogang
中科院分区：
文献类型：
--
作者：
Chen, Zhaowei;Li, Zhenhua;Qu, Xiaogang
最近对天然生物矿化分子机制的深入了解使得在温和反应条件下仿生合成功能性有机-无机杂化材料成为可能。在这里，我们描述了一种利用静电吸附的透明质酸（HA）作为磷酸钙（Cap）矿物质沉积的反应位点在介孔二氧化硅纳米颗粒上构建有机-无机杂化物的新方法。在 CaP 表面添加另一层 HA 不仅可以稳定纳米复合材料，还赋予了针对 CD44 过表达癌细胞的靶向能力。纳米材料能够在受体介导的内吞作用后在酸性亚细胞环境中控制释放负载的抗癌药物。更重要的是，我们的研究表明，癌症靶向纳米材料显着增强了细胞对乳腺癌细胞的摄取和细胞毒性。因此，这些结果为生物矿化引导的纳米结构组件开辟了新的机遇，在生物医学应用方面具有巨大的潜力。 (C) 2012 Elsevier Ltd. 保留所有权利。
Recent insight into the molecular mechanisms of natural biomineralization has enabled biomimetic synthesis of functional organic-inorganic hybrid materials under mild reaction conditions. Here, we describe a novel method to construct organic-inorganic hybrid on mesoporous silica nanoparticles by utilizing electrostatically absorbed hyaluronic acid (HA) as a reaction site for deposition of calcium phosphate (Cap) minerals. The addition of another layer of HA on the CaP surfaces not only stabilizes the nanocomposites but also confers target ability toward CD44 overexpressed cancer cells. The nanomaterials enable controlled release of loaded anticancer drugs in acidic subcellular environments after receptor mediated endocytosis. More importantly, our study demonstrated that the cancer targeting nanomaterials dramatically enhanced cellular uptake and cytotoxicity toward breast carcinoma cells. These results thus open new opportunities for biomineralization guided nanostructure assemblies with great potential for biomedical applications. (C) 2012 Elsevier Ltd. All rights reserved.