Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells
Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells
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DOI：
10.2131/jts.45.109
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发表时间：
2020-01-01
影响因子：
2
通讯作者：
Kaji, Toshiyuki
中科院分区：
文献类型：
--
作者：
Hara, Takato;Sakamaki, Sayaka;Kaji, Toshiyuki
蛋白多糖由血管内皮细胞合成，参与血管内皮细胞的增殖、迁移和凝血-纤溶系统。蛋白多糖合成的分子机制的阐明有助于理解内皮功能的调节。生物有机金属学的研究策略是以有机-无机杂化分子为工具分析生物体系。本研究发现二氯(2，9-二甲基-1，10-菲咯啉)锌(II)及其配体可调节血管内皮细胞Perlecan的表达，这种调节作用依赖于细胞密度。
Proteoglycans that are synthesized by vascular endothelial cells contribute to the proliferation, migration, and blood coagulation-fibrinolytic system in vascular endothelial cells. Clarification of the molecular mechanisms for proteoglycan synthesis allows understanding of the regulation of endothelial functions. The research strategy of bioorganometallics analyzes biological systems using organic-inorganic hybrid molecules as tools. The present study found dichloro(2,9-dimethyl-1,10-phenanthroline) zinc(II) and its ligand-modulated perlecan expression in vascular endothelial cells, which depends on the cell density.