Hepatitis B and C viral infections in patients with hepatocellular carcinoma
Hepatitis B and C viral infections in patients with hepatocellular carcinoma
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肝细胞癌患者的乙型和丙型肝炎病毒感染
DOI：
10.1002/hep.1840160305
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发表时间：
1992
期刊：
影响因子：
13.5
通讯作者：
J. Prieto
中科院分区：
文献类型：
--
作者：
J. Ruiz;B. Sangro;J. I. Cuende;O. Beloqui;JosBé I. Riezu‐Boj;J. Herrero;J. Prieto
对70例确诊为肝细胞癌的患者进行了乙型和丙型肝炎病毒感染情况的研究。用套式聚合酶链式反应检测血清中的乙肝病毒DNA和丙型肝炎病毒RNA。12例(17%)HBs Ag阳性，26例(37%)HBs和/或HBc抗体阳性，32例(46%)乙肝病毒血清标志物全部阴性。丙型肝炎病毒抗体阳性率为63%(44例)。在66名接受检测的患者中，有24人(36%)检测到乙肝病毒DNA。在这些乙肝病毒DNA阳性的患者中，12例为HBs阴性(7例HBs抗体和/或HBc抗体阳性，5例乙肝病毒血清标志物全部阴性)。68例患者中有42例(62%)检出丙型肝炎病毒RNA：丙型肝炎病毒RNA与丙型肝炎病毒抗体高度相关(95%)。然而，两名无丙型肝炎病毒抗体的患者血清中有丙型肝炎病毒RNA序列。在9名受试者(14%)中检测到两种病毒的混合感染，但这些患者与其余患者之间没有发现临床差异。我们得出的结论是，在我们的地理区域，近90%(研究的70名患者中的62例)肝细胞癌病例与肝炎病毒感染(通过血清学或分子研究发现)有关。在肝细胞癌患者中，丙型肝炎比乙肝病毒更常见，当肿瘤被诊断出来时，感染仍然活跃。这一事实可能在丙型肝炎病毒对肝细胞癌发展的贡献中起着重要作用。(《肝病》1992；16：637-641。)
The prevalence of hepatitis B and C virus infections was studied in 70 patients diagnosed as having hepatocellular carcinoma. In addition to viral serological markers, serum hepatitis B virus DNA and hepatitis C virus RNA were determined with a nested polymerase chain reaction assay. Twelve patients (17%) were HBsAg positive, 26 (37%) had antibodies to HBs, HBc or both and 32 (46%) were negative for all hepatitis B virus serological markers. Prevalence of the antibody to hepatitis C virus was 63% (44 patients). Hepatitis B virus DNA was detected in 24 of the 66 tested patients (36%). Twelve of these hepatitis B virus DNA‐positive patients were HBsAg negative (seven were positive for antibody to HBs, antibody to HBc or both and five were negative for all hepatitis B virus serological markers). Hepatitis C virus RNA was found in 42 of 68 patients (62%): A high correlation (95%) existed between hepatitis C virus RNA and hepatitis C virus antibodies. Nevertheless, two patients without antibody to hepatitis C virus had serum hepatitis C virus RNA sequences. Coinfection by the two viruses was detected in nine subjects (14%), but no clinical differences were found between these and the rest of the patients. We conclude that nearly 90% (62 of the 70 patients studied) of cases of hepatocellular carcinoma in our geographical area are related to hepatitis virus infections (detected by serological or molecular studies). Hepatitis C is more prevalent than hepatitis B virus in patients with hepatocellular carcinoma, and the infection is still active when the tumor is diagnosed. This fact is probably important in the contribution of hepatitis C virus to the development of hepatocellular carcinoma. (HEPATOLOGY 1992;16:637–641.)