Conjugation to Biocompatible Dendrimers Increases Lanthanide T(2) Relaxivity of Hydroxypyridinone (HOPO) Complexes for Magnetic Resonance Imaging (MRI).
Conjugation to Biocompatible Dendrimers Increases Lanthanide T(2) Relaxivity of Hydroxypyridinone (HOPO) Complexes for Magnetic Resonance Imaging (MRI).
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DOI：
10.1002/ejic.201101167
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发表时间：
2012-04
影响因子：
2.3
通讯作者：
Raymond, Kenneth N.
中科院分区：
文献类型：
--
作者：
Klemm, Piper J.;Floyd, William C., III;Andolina, Christopher M.;Frechet, Jean M. J.;Raymond, Kenneth N.
磁共振成像（MRI）造影剂每年在全球拥有数十亿美元的市场。虽然T1弛豫率增强造影剂受到更多关注且占据显著更大的市场份额，但由于T2弛豫率增强造影剂在高场强下弛豫率增加，其商业潜力仍然是一种可行的诊断选择。提高T2 MRI探针的对比度和生物相容性可能为MRI带来新的诊断前景。顺磁性镧系元素有可能降低T1和T2质子弛豫时间，但在MRI诊断中作为T2造影剂尚未商业化应用。在本文中，多种镧系元素的氧供体螯合物（羟基吡啶酮，HOPO和对苯二甲酰胺，TAM）被证明可作为生物相容性大分子树枝状聚合物偶联物用于开发T2 MRI探针。这些偶联物每个树枝状聚合物的弛豫率高达374 mm⁻¹s⁻¹，具有高生物利用度和低体外毒性。
Magnetic resonance imaging (MRI) contrast agents represent a worldwide billion-dollar market annually. While T1 relaxivity enhancement contrast agents receive greater attention and a significantly larger market share, the commercial potential for T2 relaxivity enhancing contrast agents remains a viable diagnostic option due to their increased relaxivity at high field strengths. Improving the contrast and biocompatibility of T2 MRI probes may enable new diagnostic prospects for MRI. Paramagnetic lanthanides have the potential to decrease T1 and T2 proton relaxation times, but are not commercially used in MRI diagnostics as T2 agents. In this article, oxygen donor chelates (hydroxypyridinone, HOPO, and terephthalamide, TAM) of various lanthanides are demonstrated as biocompatible macromolecular dendrimer conjugates for the development of T2 MRI probes. These conjugates have relaxivities up to 374 mm−1s−1 per dendrimer, high bioavailability, and low in vitro toxicity.
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影响因子：
15
作者：
Floyd WC 3rd;Klemm PJ;Smiles DE;Kohlgruber AC;Pierre VC;Mynar JL;Fréchet JM;Raymond KN
通讯作者：
Raymond KN
影响因子：
4.3
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作者：
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通讯作者：
Francis, MB
影响因子：
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作者：
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通讯作者：
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