2,4(5)-Diarylimidazoles:: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2
2,4(5)-Diarylimidazoles:: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2
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DOI：
10.1016/j.bmcl.2008.09.036
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发表时间：
2008-10-15
影响因子：
2.7
通讯作者：
Zuliani, Valentina
中科院分区：
文献类型：
--
作者：
Rivara, Mirko;Baheti, Aparna R.;Zuliani, Valentina
A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNa(v)1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Na(v)1.2 currents, emerging as a promising lead compound for further structure-activity relationship studies for the development of novel sodium channel blockers. (c) 2008 Elsevier Ltd. All rights reserved.
