Platelet-leukocyte interactions in cardiovascular disease and beyond.
Platelet-leukocyte interactions in cardiovascular disease and beyond.
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DOI：
10.1161/atvbaha.110.207480
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Evangelista V
中科院分区：
文献类型：
--
作者：
Totani L;Evangelista V
血小板-白细胞相互作用定义了一个基本的细胞过程，其特征在于血小板和不同类型的白细胞之间的信号交换，并且连接了两个基本的生理病理学事件：动脉粥样硬化血栓形成和免疫炎症反应。当这一过程发生在动脉粥样硬化斑块发展部位或内皮损伤部位时，血小板依赖性白细胞募集和活化有助于血管壁的炎症反应，这是动脉粥样硬化恶化以及内膜增生和斑块不稳定的原因。此外，血小板-白细胞相互作用可能在调节先天性和适应性免疫系统的广泛反应中起关键作用，从而有助于炎症性疾病和组织损伤的发病机制以及宿主防御。
Platelet–leukocyte interactions define a basic cell process that is characterized by the exchange of signals between platelets and different types of leukocytes, and that bridges two fundamental physiopathological events: atherothrombosis and immune–inflammatory reactions. When this process takes place at the site of atherosclerotic plaque development or at the site of endothelial injury, platelet-dependent leukocyte recruitment and activation contributes to the inflammatory reaction of the vessel wall, which accounts for the exacerbation of atherosclerosis, and for intimal hyperplasia and plaque instability. Moreover, platelet–leukocyte interactions might have a key role in modulating a wide array of responses of both the innate and adaptive immune systems, thus contributing to the pathogenesis of inflammatory diseases and tissue damage, as well as to host defense.