Developmental and pharmacological analysis of the cardiac response to an acoustic startle stimulus.
Developmental and pharmacological analysis of the cardiac response to an acoustic startle stimulus.
复制标题
心脏对声惊吓刺激的反应的发育和药理学分析。
DOI：
10.1111/j.1469-8986.1996.tb02106.x
复制
发表时间：
1996
期刊：
影响因子：
3.7
通讯作者：
Campbell,BA
中科院分区：
文献类型：
--
作者：
Richardson,R;Wang,P;Campbell,BA
本研究的目的是研究断奶前和成年大鼠对10种声惊吓刺激（0 ms上升时间，100 ms，130 dB，白色噪声刺激）的心脏反应。惊吓刺激的第一次呈现在两个年龄段都产生了心率（HR）的下降。随着持续的刺激介绍，反应转移到心动过速的成年人，但仍然心动过缓的断奶前。药理学分析表明，惊吓刺激激活的副交感神经系统在所有10个试验的断奶前大鼠。相比之下，惊吓刺激产生的副交感神经和交感神经系统在第一次审判的成年人的共激活，与副交感神经系统占主导地位，和单独的交感神经激活在以后的审判。这些结果进行了讨论，在当前的心理生理模型（a）的心脏反应惊吓刺激和（B）自主空间。
The purpose of this research was to study the cardiac response of preweanling and adult rats to 10 presentations of an acoustic startle stimulus (0 ms rise time, 100 ms, 130 dB, white noise stimulus). The first presentation of the startle stimulus produced a decrease in heart rate (HR) at both ages. With continued stimulus presentations, the response shifted to tachycardia in the adults but remained bradycardia in the preweanlings. Pharmacological analysis revealed that the startle stimulus activated only the parasympathetic system in the preweanling rats on all 10 trials. In contrast, the startle stimulus produced coactivation of the parasympathetic and sympathetic systems in the adults on the first trial, with the parasympathetic system predominating, and solely sympathetic activation on later trials. These results are discussed in terms of current psychophysiological models of (a) the cardiac response to startle stimuli and (b) autonomic space.