The Influence of Streptozotocin Diabetes on Adrenal Function in Male Rats
The Influence of Streptozotocin Diabetes on Adrenal Function in Male Rats
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链脲佐菌素对糖尿病雄性大鼠肾上腺功能的影响
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
V. G. Foglia
中科院分区：
文献类型：
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作者：
A. D. Nicola;O. Fridman;E. Castillo;V. Varga;M. Kawada;L. Aguilera;A. Ortuzar;D. Videla;Dr. L. Vargas;V. G. Foglia
雄性Wistar大鼠静脉注射。链脲佐菌素(STZ)100 mg/kg剂量。分别于糖尿病诱导后5天、1、2、3个月观察其肾上腺功能的变化。短病程糖尿病(5天)大鼠伴有肾上腺肥大和血浆皮质酮水平升高，后期糖尿病大鼠持续出现肾上腺功能亢进的征象，但肾上腺重量和血浆皮质酮水平均低于5天治疗组。用~(14)C-孕酮孵育大鼠肾上腺，结果显示糖尿病大鼠5天和1个月时合成的脱氧皮质酮均高于对照组，皮质酮和18-羟基脱氧皮质酮的产生在所有研究时间段均正常。治疗5天后，影响钠代谢的化合物18-羟基皮质酮的合成增加；此后，糖尿病大鼠的肾小球带功能似乎受损。提示糖尿病大鼠早期存在混合型肾上腺功能亢进(即糖和盐皮质激素)，后期(2~3个月)表现为慢性应激。
Male Wistar rats were treated with an i.v. dose of 100 mg/kg of Streptozotocin (STZ). Either 5 days or 1, 2 or 3 months after induction of diabetes, the adrenal function of these animals was studied. Short course diabetes (5 days) was accompanied by adrenal hypertrophy and high plasma corticosterone levels; during later periods the diabetic rats consistenly showed signs of adrenal hyperactivity, yet both adrenal weight and plasma corticosterone tended to be lower than in the 5 day-treated animals. Adrenal incubations with 14C-progesterone showed that 5 days and one month diabetic animals synthesized more deoxycorticosterone than controls; production of corticosterone and 18-hydroxydeoxycorticosterone was normal at all time periods studied. Synthesis of 18-hydroxycorticosterone, a compound which affects sodium metabolism, was increased in 5 day-treated rats; thereafter, the function of the zona glomerulosa seemed to be impaired in diabetic rats. These results suggest that early after induction of diabetes there is adrenal hyperfunction of the mixed type (i.e. gluco and mineralcorticoid), and that in the later periods (2-3 months), the deranged metabolism of the diabetic rat acts as a chronic stress.