Hyper-susceptibility to deltamethrin in parats-1 DDT resistant Drosophila melanogaster
Hyper-susceptibility to deltamethrin in parats-1 DDT resistant Drosophila melanogaster
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DOI：
10.1016/j.pestbp.2003.09.007
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发表时间：
2004-01-01
影响因子：
4.7
通讯作者：
Pittendrigh, BR
中科院分区：
文献类型：
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作者：
Pedra, JHF;Hostetler, A;Pittendrigh, BR
广泛研究的帕拉基因编码黑腹果蝇电压激活钠通道的α亚基，这是DDT和拟除虫菊酯杀虫剂的靶位点。帕拉（ts-1）果蝇品系携带隐性的性连锁的抗线虫性状（帕拉（ts-1）等位基因），该性状已根据温度敏感性麻痹的行为表型来定义。我们已经确定，除了先前注释的对DDT的抗性之外，帕拉（ts-1）还赋予对溴氰菊酯的超敏感性，揭示了负交叉抗性的存在。我们研究了利用负交互抗性转移帕拉（ts-1）基因频率在D.黑腹种群经过5代选择，帕拉（ts-1）等位基因，分别成为或多或少频繁的选择与DDT或溴氰菊酯的果蝇种群。(C)2003年爱思唯尔公司All rights reserved.
The extensively studied para gene encodes a alpha-subunit of the voltage-activated sodium channel in Drosophila melanogaster, which is the documented target site of DDT and pyrethroid insecticides. The para(ts-1) fruit fly line carries a recessive sex-linked insecticide-resistance trait (para(ts-1) allele) that has been defined on the basis of the behavioral phenotype of temperature-sensitive paralysis. We have determined that para(ts-1) confers hyper-susceptibility to deltamethrin in addition to the previously annotated resistance to DDT, revealing the presence of negative cross-re si stance. We investigated the potential use of negative cross-resistance shifting para(ts-1) gene frequencies in D. melanogaster populations. After five generations of selection, the para(ts-1) allele, respectively, became more or less frequent whether Drosophila populations were selected with DDT or deltamethrin. (C) 2003 Elsevier Inc. All rights reserved.