The Discrete Paired-trial Variable-delay T-maze Task to Assess Working Memory in Mice
The Discrete Paired-trial Variable-delay T-maze Task to Assess Working Memory in Mice
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DOI：
10.21769/bioprotoc.3664
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发表时间：
2020-07-05
期刊：
影响因子：
0.8
通讯作者：
Papaleo, Francesco
中科院分区：
文献类型：
--
作者：
Leggio, Gian Marco;Torrisi, Sebastiano Alfio;Papaleo, Francesco
Working memory abnormalities involving the prefrontal cortex (PFC) dramatically contribute to poor functional outcomes in patients with schizophrenia and still represent an unmet therapeutic need. Studies in rodents might provide essential tools to understand the mechanisms underlying PFC-dependent working memory dysfunctions, as well as precious tools for genetic and pharmacological testing. However, proper tests assessing working memory and sensitive to PFC-dependent functions must be used. In this regard, the discrete paired-trial variable-delay T-maze task, equivalent to delayed non-match to sample tasks used in humans, has proved to be an effective paradigm to test PFC-dependent working memory dysfunctions with high predictive validity in human studies.
