Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line
Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line
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DOI：
10.1017/s0007114517001143
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发表时间：
2017-05-01
影响因子：
3.6
通讯作者：
Roy, Nicole C.
中科院分区：
文献类型：
--
作者：
McCann, Mark J.;Rotjanapun, Kunjana;Roy, Nicole C.
硒是人类健康所必需的微量营养素，硒水平的波动和与之相关的潜在细胞功能障碍可能会增加疾病的风险。虽然硒已被证明影响健康中重要的几种生物学途径，但关于硒对调节这些途径的microRNA（miRNA）分子表达的影响知之甚少。为了探索硒敏感性miRNA在调节与结肠癌相关的通路中的潜在作用，我们分析了CaCo-2人腺癌细胞系中800个miRNA在低硒（72小时）应答中的表达。
Se is an essential micronutrient for human health, and fluctuations in Se levels and the potential cellular dysfunction associated with it may increase the risk for disease. Although Se has been shown to influence several biological pathways important in health, little is known about the effect of Se on the expression of microRNA (miRNA) molecules regulating these pathways. To explore the potential role of Se-sensitive miRNA in regulating pathways linked with colon cancer, we profiled the expression of 800 miRNA in the CaCo-2 human adenocarcinoma cell line in response to a low-Se (72 h at