Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons.
Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons.
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DOI：
10.1523/jneurosci.0115-12.2012
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发表时间：
2012-03-14
期刊：
影响因子：
--
通讯作者：
Hestrin S
中科院分区：
文献类型：
--
作者：
Arroyo S;Bennett C;Aziz D;Brown SP;Hestrin S
大脑皮层尼古丁受体的胆碱能激活在觉醒、注意力和学习中起着关键作用。在这里，我们证明了来自小鼠基底前脑的胆碱能轴突通过一种非常缓慢的、非α7烟碱受体介导的传导来兴奋特定的皮质中间神经元亚群。反过来，这些抑制细胞在邻近的大脑皮层神经元中产生延迟和延长的双突触抑制波，改变大脑皮层回路中抑制的时空模式。
Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Here we demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.