TEMPORAL-LOBE REGIONS ON MAGNETIC-RESONANCE-IMAGING IDENTIFY PATIENTS WITH EARLY ALZHEIMERS-DISEASE
TEMPORAL-LOBE REGIONS ON MAGNETIC-RESONANCE-IMAGING IDENTIFY PATIENTS WITH EARLY ALZHEIMERS-DISEASE
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DOI：
10.1001/archneur.1993.00540090052010
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发表时间：
1993-09-01
影响因子：
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通讯作者：
JOLESZ, F
中科院分区：
文献类型：
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作者：
KILLIANY, RJ;MOSS, MB;JOLESZ, F
目的：该研究的目的是检查一组轻度受损的阿尔茨海默病 (AD) 患者的选定大脑区域的体积。选择了五个区域进行分析，据报道，所有这些区域都显示大多数 AD 患者在疾病过程中的某个时间发生了实质性变化。设计。-实验者“盲法”的病例对照研究。设置。-医院磁共振成像中心。参与者。-15 名受试者，其中 8 名患者被诊断为可能的阿尔茨海默型痴呆，与国家神经和交流疾病研究所一致，中风/阿尔茨海默氏病及相关疾病协会标准和七名年龄匹配的健康对照受试者。结果-AD 患者和对照者之间的三个体积测量值显着不同：海马体、侧脑室颞角和颞叶。其中两项措施并未显着区分 AD 患者和对照组：杏仁核和基底前脑。判别函数分析表明，海马体和侧脑室颞角体积的线性组合可将患者和对照组 100% 区分开来。结论：结果表明，海马体和侧脑室颞角可作为轻度受损患者 AD 的生前标记。
Objective.-The goal of the study was to examine the volume of selected brain regions in a group of mildly impaired patients with Alzheimer's disease (AD). Five regions were selected for analysis, all of which have been reported to show substantial change in the majority of patients with AD at some time in the course of disease.Design.-Case-control study with the experimenter ''blinded.'' Setting.-Hospital-based magnetic resonance imaging center.Participants.-Fifteen subjects, eight patients with the diagnosis of probable dementia of the Alzheimer type made in concordance with National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association criteria and seven age-matched healthy control subjects.Results.-Three of the volumetric measures were significantly different between patients with AD and controls: the hippocampus, the temporal horn of the lateral ventricles, and the temporal lobe. Two of the measures did not significantly differentiate patients with AD and controls: the amygdala and the basal forebrain. A discriminant function analysis demonstrated that a linear combination of the volumes of the hippocampus and the temporal horn of the lateral ventricles differentiated 100% of the patients and controls from one another.Conclusions.-The results suggest that the hippocampus and the temporal horn of the lateral ventricles may be useful as antemortem markers of AD in mildly impaired patients.