Polypeptide hydrogels via a unique assembly mechanism
Polypeptide hydrogels via a unique assembly mechanism
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DOI：
10.1039/b500307e
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发表时间：
2005-06-14
期刊：
影响因子：
3.4
通讯作者：
Deming, TJ
中科院分区：
文献类型：
--
作者：
Deming, TJ
人类使用由肽和蛋白质衍生的材料有着悠久的历史。这些天然材料具有纳米级自组装的复杂机制，这激发了许多合成和生物合成氨基酸基材料的设计。这些材料是有吸引力的，因为它们可以具有特殊的性质、环境响应行为、生物活性，并且可以被代谢。由于其复杂性，肽和蛋白质主要依赖于两种基本的自组装模式：β链的缔合和螺旋的卷曲。在这种情况下，一类最近合成和表征的多肽材料在这里进行了审查，这是发现自组装的一个根本不同的过程。发现这种新的组装模式产生具有独特的性质组合（例如热稳定性和可注射性）的多肽水凝胶，使其对于食品、个人护理产品和药物中的应用具有吸引力。
There is a long history of man's use of materials derived from peptides and proteins. These natural materials possess sophisticated mechanisms of nanoscale self assembly, which have inspired the design of many synthetic and biosynthetic amino-acid based materials. These materials are attractive since they can have exceptional properties, environmental responsive behavior, biological activity, and can be metabolized. With all of their complexity, peptides and proteins rely primarily on two fundamental modes of self assembly: association of beta-strands and the coiling of helices. In this context, a class of recently synthesized and characterized polypeptide materials are reviewed here, which were found to self-assemble by a fundamentally different process. This new mode of assembly was found to give rise to polypeptide hydrogels with a unique combination of properties (e.g. heat stability and injectability) making them attractive for applications in foods, personal care products, and medicine.