Influence of hyperbranched multi-methacrylates for dental neat resins on proliferation of human gingival fibroblasts.
Influence of hyperbranched multi-methacrylates for dental neat resins on proliferation of human gingival fibroblasts.
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DOI：
10.1021/bm000101p
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发表时间：
2001
影响因子：
6.2
通讯作者：
Q. Wan;D. Rumpf;S. Schricker;A. Mariotti;B. M. Culbertson
中科院分区：
文献类型：
--
作者：
Q. Wan;D. Rumpf;S. Schricker;A. Mariotti;B. M. Culbertson
我们之前已经证明，与2，2-双[4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基]丙烷/三甘醇二甲基丙烯酸酯（BisGMA/TEGDMA）纯树脂相比，超支化多甲基丙烯酸酯（H-MMA）改性的牙科树脂具有VLC活性、较低的聚合收缩率和改善的机械性能。这是由于H-MMA中间体具有独特的分子结构和高分子量。本研究的目的是评价H-MMA改性牙科纯树脂的生物相容性。检查了三种人牙龈成纤维细胞株在H-MMA、BisGMA/TEGDMA或聚苯乙烯盘上的细胞增殖。细胞增殖10天后，H-MMA改性和未改性树脂盘之间的细胞数量没有统计学差异。H-MMA改性的树脂比未改性的树脂具有更少的游离单体浸出，但在吸水性和接触角值方面表现出相似的性质。这些结果表明，H-MMA改性牙科纯树脂的生物相容性与市售BisGMA/TEGDMA树脂相当，H-MMA在牙科复合材料中具有潜在的应用价值。
We have previously shown that hyperbranched multi-methacrylate (H-MMA)-modified dental resins have VLC activities, lower polymerization shrinkage, and improved mechanical properties, compared to the 2,2-bis[4-(2-hydroxy-3-methacryloyolxypropoxy)phenyl]propane/triethyleneglycol dimethacrylate (BisGMA/TEGDMA) neat resin. The results are due to the unique molecular structure and high molecular weight of H-MMA intermediates. The purpose of this study was to evaluate the biocompatibility of H-MMA-modified dental neat resins. The cell proliferation of three human gingival fibroblast strains on either H-MMA, BisGMA/TEGDMA, or a polystyrene disk was examined. Following 10 days of cell proliferation, there was no statistical difference in cell number between H-MMA-modified and unmodified resin disks. H-MMA-modified resins had less free monomer leaching than the unmodified resin but showed similar properties in water sorption and contact angle values. All these results suggest that the biocompatibility of H-MMA-modified dental neat resins is as good as that of commercially used BisGMA/TEGDMA resin and H-MMA has potential applications in dental composites.