Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels
Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels
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日本人膳食砷不同化学种类的摄入量及其血液和尿液砷水平
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
Y. Yamamura
中科院分区：
文献类型：
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作者：
H. Yamauchi;Keiko Takahashi;M. Mashiko;Juichiro Saitoh;Y. Yamamura
我们计算了典型的日本人的饮食砷的每种化学物质的摄入量，并确定了尿液和血液中的砷的每种化学物质的水平。35名志愿者的平均总砷摄入量为195±235（15.8-1039）μg As，由76%的三甲基砷（TMA）、17.3%的无机砷（Asi）、5.8%的二甲基砷（DMA）和0.8%的单甲基砷（MA）组成：TMA的摄入量是所有测量物种中最大的。Asi的摄入是每餐中特有的，并且总是发生在每餐中。在摄入的Asi中，45-75%在体内被甲基化形成MA和DMA，并以这些形式排泄到尿液中。56名健康志愿者尿中总砷含量为129±92.0 μg·dm-3，由64.6%TMA、26.7%DMA、6.7%Asi和2.2%MA组成。56名志愿者的平均血液总砷水平为0.73±0.57 μg dl−1，由73%的TMA、14%的DMA和9.6%的Asi组成。尿TMA与全血TMA呈显著正相关（r = 0.376; P<0.01）。
We calculated the intake of each chemical species of dietary arsenic by typical Japanese, and determined urinary and blood levels of each chemical species of arsenic. The mean total arsenic intake by 35 volunteers was 195±235 (15.8-1039) μg As day−1, composed of 76% trimethylated arsenic (TMA), 17.3% inorganic arsenic (Asi), 5.8% dimethylated arsenic (DMA), and 0.8% monomethylated arsenic (MA): the intake of TMA was the largest of all the measured species. Intake of Asi characteristically and invariably occurred in each meal. Of the intake of Asi, 45-75% was methylated in vivo to form MA and DMA, and excreted in these forms into urine. The mean measured urinary total arsenic level in 56 healthy volunteers was 129±92.0 μg As dm−3, composed of 64.6% TMA, 26.7% DMA, 6.7% Asi and 2.2% MA. The mean blood total arsenic level in the 56 volunteers was 0.73±0.57 μg dl−1, composed of 73% TMA, 14% DMA and 9.6% Asi. The urinary TMA levels proved to be significantly correlated with the whole-blood TMA levels (r = 0.376; P<0.01).