Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?
Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?
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DOI：
10.1016/s0006-291x(02)00307-8
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发表时间：
2002-05-10
影响因子：
3.1
通讯作者：
Korenberg, JR
中科院分区：
文献类型：
--
作者：
Barlow, GM;Micales, B;Korenberg, JR
中枢神经系统(CNS)的发育包括神经构型、神经元和轴突迁移。和突触的形成。Dscam是一种21号染色体轴突引导分子，在发育过程中和整个成年生活中都由中枢神经系统神经元表达。我们现在报道，DSCAM及其11号染色体旁系DSCAML1在发育中的脊髓中表现出反向的腹背向表达模式。部分相反，在发育中的皮质中的表达模式。从卡哈尔-雷祖斯细胞开始。在成人大脑皮层。DSCAM主要分布于第3/5层锥体细胞，DSCAML1主要分布于第2层颗粒细胞。在小脑中，DSCAM在浦肯野细胞中表达较强，DSCAML1在颗粒细胞中表达较强。最后，我们发现所预测的DSCAML1蛋白含有60个额外的N端氨基酸，这可能与其独特的表达模式和推测的功能有关。我们认为在发育中的中枢神经系统中，DSCAM包括调节背腹模式和细胞命运指定的通路的新元件。(C)2002年埃尔塞维尔科学公司(美国)。版权所有。
Central nervous system (CNS) development involves neural patterning, neuronal and axonal migrations. and synapse formation. DSCAM, a chromosome 21 axon guidance molecule, is expressed by CNS neurons during development and throughout adult life. We now report that DSCAM and its chromosome 11 paralog DSCAML1 exhibit inverse ventral-dorsal expression patterns in the developing spinal cord and distinct. partly inverse, expression patterns in the developing cortex. beginning in the Cajal-Retzius cells. In the adult cortex. DSCAM predominates in layer 3/5 pyramidal cells and DSCAML1 predominates in layer 2 granule cells. In the cerebellum, DSCAM is stronger in the Purkinje cells and DSCAML1 in the granule cells. Finally, we find that the predicted DSCAML1 protein contains 60 additional N-terminal amino acids which may contribute to its distinct expression pattern and putative function. We propose that the DSCAMs comprise novel elements of the pathways mediating dorsal-ventral patterning and cell-fate specification in the developing CNS. (C) 2002 Elsevier Science (USA). All rights reserved.