Evaluation of liver fibrosis: "Something old, something new…".
Evaluation of liver fibrosis: "Something old, something new…".
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DOI：
10.20524/aog.2016.0046
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发表时间：
2016-10
影响因子：
2.2
通讯作者：
Tiniakos D
中科院分区：
文献类型：
--
作者：
Almpanis Z;Demonakou M;Tiniakos D
肝纤维化可逐渐导致肝硬化，这是由于细胞外基质成分作为对肝损伤的反应而积累。因此，慢性肝病的治疗决策，无论原因如何，首先应该通过准确定量肝纤维化来指导。肝纤维化程度的检测和评估是现代肝病学的一个挑战。虽然传统的组织学分期系统仍然是“最佳标准”，但它们不能将肝纤维化量化为动态过程，并且可能不能准确地对肝硬化进行亚分期。本综述旨在比较目前使用的非侵入性方法测量肝纤维化，并提供更新，目前基于组织的数字技术为此目的而开发，这可能会证明在日常临床实践中的价值。
Hepatic fibrogenesis may gradually result to cirrhosis due to the accumulation of extracellular matrix components as a response to liver injury. Thus, therapeutic decisions in chronic liver disease, regardless of the cause, should first and foremost be guided by an accurate quantification of hepatic fibrosis. Detection and assessment of the extent of hepatic fibrosis represent a challenge in modern Hepatology. Although traditional histological staging systems remain the “best standard”, they are not able to quantify liver fibrosis as a dynamic process and may not accurately substage cirrhosis. This review aims to compare the currently used non-invasive methods of measuring liver fibrosis and provide an update in current tissue-based digital techniques developed for this purpose, that may prove of value in daily clinical practice.