SAFE, LIVE VIBRIO-CHOLERAE VACCINES
SAFE, LIVE VIBRIO-CHOLERAE VACCINES
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DOI：
10.1016/s0264-410x(88)80019-7
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发表时间：
1988-04-01
期刊：
影响因子：
5.5
通讯作者：
MEKALANOS, J
中科院分区：
文献类型：
--
作者：
TAYLOR, R;SHAW, C;MEKALANOS, J
已经构建了肠道定植缺陷的霍乱弧菌突变体。这些突变体的特征导致了一个基因簇的鉴定，该基因簇参与了一种称为TCP的菌毛定植因子的组装。tcpoperon已被克隆，v。霍乱菌已被构建为过量产生这种菌毛和霍乱毒素的B亚基。总之，这些研究可能有助于最终构建有效的口服霍乱活疫苗和灭活疫苗。
Mutants ofVibrio choleraedefective in intestinal colonization have been constructed. Characterization of these mutants has led to the identification of a gene cluster involved in the assembly of a pilus colonization factor called TCP. Thetcpoperon has been cloned and strains ofV. choleraehave been constructed that overproduce this pilus and the B subunit of cholera toxin. Together these studies may contribute to the eventual construction of efficient live and killed, oral cholera vaccines.