Evaluation of a plasticity-based cognitive training program in schizophrenia: Results from the eCaesar trial
Evaluation of a plasticity-based cognitive training program in schizophrenia: Results from the eCaesar trial
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DOI：
10.1016/j.schres.2019.03.006
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发表时间：
2019-06-01
影响因子：
4.5
通讯作者：
Keefe, Richard S. E.
中科院分区：
文献类型：
--
作者：
Mahncke, Henry W.;Kim, Sarah-Jane;Keefe, Richard S. E.
目的：认知功能障碍是精神分裂症的核心特征。计算机化认知训练在试点研究中显示出了希望。一项为期26周的随机盲安慰剂对照试验进行了调查的影响，一种新的计算机化认知训练计划对认知和功能的能力outcomes.Method：本研究遵循MATRICS指南的干预措施，旨在改善精神分裂症的认知功能的评估。参与者（N = 150）被随机分配到实验组（以类似游戏的形式进行计算机认知训练）或主动控制组（计算机游戏）。培训在诊所进行，预期培训时间表为每周5天，每天1小时，持续26周。共同主要结局指标为MATRICS共识认知成套测验（MCCB）综合评分和UCSD基于表现的技能评估（UPSA-2）总分，次要结局指标包括认知评估访谈（CAI）和简明12心理综合评分（SF-12 MCS）。结果：在基线时，各组匹配良好。与活性对照相比，实验治疗对主要或次要结局指标无显著影响。任务学习/目标参与数据的审查建议不充分的目标engagement.Conclusions：结果不支持的认知或功能能力的好处，从这个实施的计算机化认知训练计划的人精神分裂症。在未来的试验中，仔细考虑是值得的任务学习/目标参与的评估，使认知训练游戏的动机的影响，以及试验要求对参与者选择的隐含影响。(C)2019年，任作家。由爱思唯尔公司出版
Objective: Cognitive impairment in schizophrenia is a core feature of the disorder. Computerized cognitive training has shown promise in pilot studies. A 26-week randomized blinded placebo-controlled trial was conducted to investigate the effect of a novel computerized cognitive training program on cognitive and functional capacity outcomes.Method: The study followed MATRICS guidelines for the evaluation of interventions designed to improve cognitive function in schizophrenia. Participants (N = 150) were randomized to experimental (computerized cognitive training in a game-like format) or active control (computer games) groups. Training was conducted in-clinic, with an intended training schedule of 5 days per week, 1 h per day, for 26 weeks. Co-primary outcome measures were the MATRICS Consensus Cognitive Battery (MCCB) composite score and the UCSD Performance-Based Skills Assessment (UPSA-2) total score, secondary outcome measures included the Cognitive Assessment Interview (CAI) and the Short-Form-12 Mental Composite Score (SF-12 MCS). Target engagement was assessed with task-learning based assessment.Results: At baseline, the groups were well matched. No significant effect of the experimental treatment was seen on the primary or secondary outcome measures compared to the active control. Review of the task learning/target engagement data suggested inadequate target engagement.Conclusions: Results do not support a cognitive or functional capacity benefit from this implementation of a computerized cognitive training program in people with schizophrenia. In future trials, careful consideration is merited of the assessment of task learning/target engagement, the effects of making the cognitive training game-like on motivation, and the implicit effects of trial requirements on participant selection. (C) 2019 The Authors. Published by Elsevier B.V.