Diffusion tensor imaging in early Alzheimer's disease
Diffusion tensor imaging in early Alzheimer's disease
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DOI：
10.1016/j.pscychresns.2006.01.005
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发表时间：
2006-04-30
影响因子：
2.3
通讯作者：
Meder, JF
中科院分区：
文献类型：
--
作者：
Naggara, O;Oppenheim, C;Meder, JF
我们的目的是探讨白色组织损害的程度在早期阿尔茨海默病（AD）患者使用扩散张量磁共振成像（DTI）。虽然AD病理主要影响皮质灰质，但先前的磁共振成像（MRI）研究表明，白色物质（WM）也存在变化。然而，AD相关WM损害的性质仍不清楚。12例早期AD患者（简易精神状态检查[MMSE]评分= 27，Grober和Buschke测试评分= 33.2，数字广度评分= 5.6）和12名性别和年龄匹配的志愿者进行常规和DTI检查（B = 1000 s/mm（2），25个方向）。将每例患者和对照组的几个WM区域的右侧和左侧平均扩散率（MD）和各向异性分数（FA）合并，并在两组之间进行比较。比较两组全脑体积及颞叶萎缩程度。AD患者胼胝体压部MD增加，额叶和顶叶WM MD增加。与对照组相应区域相比，双侧颞叶、额叶和压部的W-M FA降低。其他区域（枕区、上级颞区、扣带、内囊和胼胝体的前角）的值在患者和对照组之间没有差异。MMSE评分与各向异性指数之间无相关性。DTI显示早期AD患者额叶和颞叶WM异常。这些变化与早期颞-额神经切断相一致。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Our aim was to investigate the extent of white matter tissue damage in patients with early Alzheimer disease (AD) using diffusion tensor magnetic resonance imaging (DTI). Although AD pathology mainly affects cortical grey matter, previous magnetic resonance imaging (MRI) studies showed that changes also exist in the white matter (WM). However, the nature of AD-associated WM damage is still unclear. Conventional and DTI examinations (b = 1000 s/mm(2), 25 directions) were obtained from 12 patients with early AD (Mini Mental State Examination [MMSE] score = 27, Grober and Buschke test score = 33.2, digit span score = 5.6) and 12 sex- and age-matched volunteers. The right and left mean diffusivity (MD) and fractional anisotropy (FA) of several WM regions were pooled in each patient and control, and compared between the two groups. Volumes of the whole brain and degree of atrophy of the temporal lobe were compared between the two groups. In AD, MD was increased in the splenium of the corpus callosum and in the WM in the frontal and parietal lobes. FA was bilaterally decreased in the W-M of the temporal lobe, the frontal lobe and the splenium compared with corresponding regions in controls. Values in other areas (occipital area, superior temporal area, cingulum, internal capsule, and genu of the corpus callosum) were not different between patients and controls. No correlations were found between the MMSE score and the anisotropy indices. Findings of DTI reveal abnormalities in the frontal and temporal WM in early AD patients. These changes are compatible with early temporal-to-frontal disconnections. (c) 2006 Elsevier Ireland Ltd. All rights reserved.