MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases
MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases
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DOI：
10.1007/s11010-011-1052-6
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发表时间：
2012-01-01
影响因子：
4.3
通讯作者：
Zou, Fangdong
中科院分区：
文献类型：
--
作者：
Li, Si;Liang, Zhu;Zou, Fangdong
MiRNAs是一类新的小RNA分子，在转录后和翻译水平上调节基因的表达。MiRNAs参与了许多重要的生物学过程的调控，包括发育、细胞增殖、分化和凋亡。越来越多的研究表明，miRNAs在癌症发生和其他疾病中也发挥着重要作用。在已鉴定的miRNA中，miRNA-21在不同来源的癌细胞中显著上调。它调控广泛的基因和途径，涉及癌症的启动、转化、侵袭和转移。MiRNA-21在心血管疾病中也是一种促进生存的因子。在这些疾病中的异常表达使miRNA-21成为疾病诊断和预后的潜在标记物。本文就miRNA-21在癌症和心血管疾病中的复杂作用及其潜在的临床应用作一综述。
MiRNAs are a new class of small RNA molecules that regulate gene expression at the post-transcriptional and translational levels. MiRNAs have been implicated in the control of many vital biological processes including development, cell proliferation, differentiation, and apoptosis. A growing number of studies have shown that miRNAs also play an important role in carcinogenesis and other diseases. Among the miRNAs identified, miRNA-21 is dramatically up-regulated in cancer cells of various origins. It regulates a wide range of genes and pathways involved in cancer initiation, transformation, invasion, and metastasis. MiRNA-21 also acts as a pro-survival factor in cardiovascular diseases. Aberrant expression in these diseases makes miRNA-21 a potential marker for disease diagnosis and prognosis. This review highlights the complex roles that miRNA-21 plays in cancer and cardiovascular diseases and its potential clinical applications.