Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population
Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population
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DOI：
10.1016/j.ahj.2003.12.020
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发表时间：
2004-06-01
影响因子：
4.8
通讯作者：
Ueshima, H
中科院分区：
文献类型：
--
作者：
Okamura, T;Hayakawa, T;Ueshima, H
背景 几项前瞻性研究报告称，静息心率 (HR) 是某些特定原因死亡的危险因素，同时 HR 对死亡的影响存在性别或年龄差异。然而，来自非西方人群的前瞻性数据很少。 方法 队列研究，截至死亡或随访结束（1998 年 11 月 15 日）为止超过 16.5 年，涉及日本各地随机选择的 8800 名大于或等于 30 岁的男性和女性，他们参加了 1980 年的全国循环系统疾病调查。静息 HR 是根据 R 波之间的 3 个连续间隔确定的。 12 导联心电图。 结果 对于中年男性（30 至 59 岁），在 HR 的最高四分位数中，与心血管（RR，2.55；95% CI，1.22 至 5.31）和全因死亡（RR，1.45；95% CI，1.06 至 2.00）呈显着正相关。对于中年女性，在最高四分位数中，与非癌症、非心血管疾病（RR，2.41；95% CI，1.04至5.59）和全因死亡（RR，1.94；95% CI，1.26至3.01）呈显着正相关。静息心率也显示与心脏事件呈显着正相关，但与中风无关。对于老年受试者（大于或等于 60 岁），这些关系并不明显。当排除随访前 5 年内的死亡（非癌症、非心血管死亡除外）时，结果不会受到影响。结论 高静息 HR 是日本普通人群长期死亡的独立预测因子。
Background Several prospective studies have reported resting heart rate (HR) to be a risk factor for certain cause-specific death, together with sex- or age-specific differences in the effects of HR on death. However, there have been few prospective data from non-Western populations.Methods Cohort study, over 16.5 years to date of death or end of follow-up (November 15, 1998) involving 8800 men and women greater than or equal to30 years of age randomly selected throughout Japan, who participated in the National Survey on Circulatory Disorders in 1980. Resting HR was determined from 3 consecutive intervals between R waves on the 12-lead electrocardiogram.Results For middle-aged men (30 to 59 years of age), in the highest quartile of HR, there was a significant positive association with cardiovascular (RR, 2.55; 95% CI, 1.22 to 5.31) and all-cause death (RR, 1.45; 95% CI, 1.06 to 2.00). For middle-aged women, in the highest quartile, there was a significant positive association with noncancer, noncardiovascular (RR, 2.41; 95% CI, 1.04 to 5.59), and all-cause death (RR, 1.94; 95% CI, 1.26 to 3.01). Resting HR also showed a significant positive association with cardiac events but not to stroke. These relations were not evident for elderly subjects (greater than or equal to60 years of age). Results were not affected when deaths within the first 5 years of follow-up were excluded, except for noncancer, noncardiovascular death.Conclusions High resting HR is an independent predictor of long-term death in the Japanese general population.