Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer.
Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer.
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Hippo/TEAD4信号通路作为乳腺癌治疗的潜在靶点。
DOI：
10.3892/ol.2021.12574
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发表时间：
2021-04
期刊：
影响因子：
2.9
通讯作者：
Hu C
中科院分区：
文献类型：
--
作者：
Wu Y;Li M;Lin J;Hu C
乳腺癌是全世界妇女中最常见的癌症类型。Hippo信号通路与细胞增殖、迁移、侵袭、转移和对乳腺癌治疗的抗性密切相关。Hippo信号通路的上游因子包括哺乳动物Ste 20激酶1/2、大肿瘤抑制激酶1/2和转录辅激活因子Yes相关蛋白（雅普）/转录辅激活因子PDZ结合基序（TAZ），它们被认为是乳腺癌治疗的靶点，因此被广泛研究。最近，已经表明转录增强因子结构域（TEAD）家族的转录因子，特别是TEAD 4，在乳腺癌中起重要作用。TEAD与雅普/TAZ相互作用以充当转录因子。值得注意的是，最近的研究表明，TEAD 4也可以以雅普/TAZ非依赖性方式发挥作用，并作为乳腺癌的预后标志物。本文就Hippo信号通路异常激活对乳腺癌进展的影响作一综述。此外，TEAD家族在乳腺癌中的作用的最新进展突出，TEAD 4作为乳腺癌治疗干预的潜在靶点的作用进行了讨论。
Breast cancer is the most common type of cancer among women worldwide. The Hippo signaling pathway is strongly associated with cell proliferation, migration, invasion, metastasis and resistance to breast cancer treatment. The upstream factors involved in the Hippo signaling pathway, including mammalian Ste20 kinases 1/2, large tumor suppressor kinases 1/2 and transcription coactivator Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ), have been extensively studied as they are considered therapeutic targets for breast cancer. Recently, it has been suggested that the transcriptional enhancer factor domain (TEAD) family of transcription factors, particularly TEAD4, plays an important role in breast cancer. TEADs interact with YAP/TAZ to act as transcription factors. Notably, recent studies have demonstrated that TEAD4 may also function in a YAP/TAZ-independent manner and serve as a prognostic marker for breast cancer. The present review summarizes the current research on the effect of the aberrant activation of the Hippo signaling pathway on breast cancer progression. Furthermore, the latest advances on the role of the TEAD family in breast cancer are highlighted, and the role of TEAD4 as a potential target for therapeutic intervention in breast cancer is discussed.
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影响因子：
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作者：
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DOI：
10.1073/pnas.1101273108
发表时间：
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影响因子：
11.1
作者：
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通讯作者：
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