Electrophysiological evidence for delayed mismatch response in infants at-risk for specific language impairment
Electrophysiological evidence for delayed mismatch response in infants at-risk for specific language impairment
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DOI：
10.1111/j.1469-8986.2004.00202.x
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发表时间：
2004-09-01
期刊：
影响因子：
3.7
通讯作者：
Friederici, AD
中科院分区：
文献类型：
--
作者：
Friedrich, M;Weber, C;Friederici, AD
本研究探讨是否延迟听觉处理通常发现在儿童与特定语言障碍（SLI）已经可以观察到的事件相关电位的2个月大的婴儿。有和没有SLI家族史的婴儿进行了测试，在一个被动的听觉oddball范式与CV音节不同的元音持续时间。对于长音节，偏离波和标准波之间的差异波出现了正的失配反应。其振幅在安静睡眠的婴儿高于清醒的婴儿，虽然其峰值潜伏期仍然不受警觉。清醒的婴儿表现出成人样的不匹配的负之前的积极性。SLI的风险反映在阳性错配反应的潜伏期，与无风险的婴儿相比，有风险的婴儿的潜伏期延迟。这种潜伏期差异表明，2个月大的婴儿在处理持续时间的听觉刺激变化时已经受到SLI风险的影响。
The present study investigated whether delayed auditory processing typically found in children with specific language impairment (SLI) can already be observed in the event-related potentials of 2-month-old infants. Infants with and without a family history of SLI were tested in a passive auditory oddball paradigm with CV-syllables differing in vowel duration. For the long syllable, a positive mismatch response occurred in the difference wave between deviant and standard. Its amplitude was higher in infants during quiet sleep than in awake infants, although its peak latency remained unaffected by alertness. Awake infants showed an adultlike mismatch negativity preceding the positivity. Risk for SLI was reflected in the latency of the positive mismatch response, which was delayed in infants with risk compared to infants without risk. This latency difference suggests that 2-month-old infants at risk for SLI are already affected m processing an auditory stimulus change of duration.