Glycoprotein contributions to mammary gland and mammary tumor structure and function: Roles of adherens junctions, ErbBs and membrane MUCs
Glycoprotein contributions to mammary gland and mammary tumor structure and function: Roles of adherens junctions, ErbBs and membrane MUCs
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DOI：
10.1002/jcb.20612
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发表时间：
2005-12-01
影响因子：
4
通讯作者：
Carraway, CAC
中科院分区：
文献类型：
--
作者：
Carraway, KL;Ramsauer, VP;Carraway, CAC
乳腺的功能依赖于它的三维组织，这种三维组织是由细胞黏附连接通过细胞膜连接到细胞细胞骨架来建立和维持的。这些连接不仅可以作为结构元件，还可以作为细胞信号的启动子和整合子。在这篇综述中，我们讨论了三类相互作用影响乳腺细胞-细胞连接功能的糖蛋白：钙粘附素、ErbB受体酪氨酸激酶和膜粘蛋白，它们是调控乳腺细胞行为的事件的一个缩影。这些成分的作用被关键的信号元件β-连环蛋白整合在一起。当功能正常时，这些糖蛋白、β-连环蛋白和相关的信号通路结合成一个高度结构化的程序，促进腺体的发育和功能。然而，这些糖蛋白或信号元件的破坏或功能障碍会导致上皮细胞的紊乱，最终导致肿瘤的发生。
Mammary function is dependent on its three-dimensional organization, which is established and maintained by cell adhesive junctions linked through the membrane to the cell cytoskeleton. These junctions serve not only as structural elements, but also function as initiators and integrators of cell signals. In this review we discuss three types of glycoproteins whose interactions impinge on the function of mammary cell-cell junctions, cadherins, ErbB receptor tyrosine kinases and membrane mucins, as a microcosm of events regulating mammary cell behaviors. Actions of these components are integrated by the critical signaling element beta-catenin. When functioning properly, these glycoproteins, beta-catenin and associated signaling pathways mesh into a highly structured program for development and function of the gland. However, disruption or dysfunction of these glycoproteins or the signaling elements can lead to disorganization of the epithelia and ultimately to neoplasia.