Relationship between tubulo-glomerular feedback responses and perfusate hypotonicity.
Relationship between tubulo-glomerular feedback responses and perfusate hypotonicity.
复制标题
肾小管-肾小球反馈反应与灌注液低渗性之间的关系。
DOI：
10.1038/ki.1982.160
复制
发表时间：
1982
影响因子：
19.6
通讯作者：
Navar,LG
中科院分区：
文献类型：
--
作者：
Bell,PD;Navar,LG
Relationship between tubulo-glomerular feedback responses and per-fusate hypotonicity. Previous studies have established that during ortho-grade perfusion from a late proximal tubule site, there is a direct relationship between the magnitude of the feedback response and the level of distal tubular fluid sodium chloride concentration. The present study was conducted in the rat to extend this observation by assessing stop flow pressure (SFP) feedback responses during retrograde perfusion into the early distal tubule with solutions varying in total solute concentration and in the anionic constituent. SFP was measured after blockade of the intermediate proximal and late distal tubular segments with wax. Retrograde perfusion was initiated from an early distal tubular site at 15 nl/min. All solutions contained a 38 mOsm/kg matrix base, and the total solute concentration was increased with either sodium chloride or sodium isethionate to achieve osmolalities of 68, 85, and 120 mOsm/kg. For comparison, feedback responses during perfusion with a 120 mOsm/kg choline chloride solution were evaluated. During perfusion with the 120 mOsm/kg solutions, SFP decreased by 13 1.3 mm Hg with the sodium chloride solution, 12 1.5 mm Hg with the sodium isethionate solution, and 12 1.3 mm Hg with the choline chloride solution. During perfusion with solutions having an osmolality of 85 mOsm/kg, SFP decreased by 8 1.3 mm Hg with sodium chloride and 8 0.8 mm Hg with sodium isethionate. The 68 mOsm/kg solutions elicited decreases in SFP of 4.4 0.4 mm Hg and 5 0.5 mm Hg. During perfusion with the 38 mOsm/kg matrix solution, SFP decreased by an average of 1.4 0.9 mm Hg. Linear regression analysis revealed a 1 mm Hg decrease in SFP for every 7.7 mOsm/kg decrease in perfusate osmolality below 120 mOsm/kg. These results confirm previous findings that the magnitude of the feedback response is associated closely with the concentration of the perfusate over a narrow range from 38 to 120 inOsm/kg. Since the responses with sodium isethionate solutions were similar to the responses obtained with sodium chloride containing solutions, these studies provide evidence that the magnitude of the feedback responses are not specifically dependent on alterations in chloride concentration.Relation entre le rétro-contrôle tubulo-glomérulaire et l'hypotonicité du perfusat. Des etudes antérieures ont établi que pendant une perfusion orthograde, a partir d'un point situé dans le tubule proximal terminal, il ya une relation directe entre l'importance du rCtro-contrôle et La concentration du chiorure de sodium dans Ic fluide tubulaire distal. La présente étude a Cté entreprise chez le rat aim d'étendre cette observation en determinant les responses feedback de pression d'interruption du debit (SFP) au cours d'une perfusion retrograde dans Ic tubule distal initial, avec des solutions dont les concentrations totales en solutes ou en leur constituant anionique étaient variables. La SFP a etC mesurée après blocage des segments tubulaires proximal intermédiaire et distal terminal avec de la cire. La perfusion retrograde a été initiée a partir
登录
查看更多内容
肾小球血流、压力和滤过率的反馈控制。
影响因子：
33.6
作者：
F. Wright;J. Briggs
通讯作者：
J. Briggs
肾小管内 Na 和 Cl 离子替代对肾小管肾小球反馈运作的影响。
DOI：
10.1111/j.1748-1716.1978.tb06228.x
发表时间：
1978
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
R. Müller;H. Gutsche
通讯作者：
H. Gutsche
大鼠非电解质溶液灌注过程中的肾小球反馈反应。
影响因子：
19.6
作者：
Bell,PD;Navar,LG;Ploth,DW;McLean,CB
通讯作者：
McLean,CB
细胞质钙介导致密斑肾小管肾小球反馈反应。
DOI：
10.1126/science.6800034
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bell,PD;Navar,LG
通讯作者：
Navar,LG
肾血流动力学和自动调节的远端肾小管反馈控制。
影响因子：
18.2
作者：
L. Navar;D. Ploth;P. Bell
通讯作者：
P. Bell