A TECHNIQUE FOR HEART TRANSPLANTATION IN THE RAT.
A TECHNIQUE FOR HEART TRANSPLANTATION IN THE RAT.
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大鼠心脏移植技术。
DOI：
10.1001/archsurg.1964.01320040061009
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发表时间：
1964
影响因子：
--
通讯作者：
C. Dewitt
中科院分区：
文献类型：
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作者：
C. Abbott;E. S. Lindsey;O. Creech;C. Dewitt
迄今为止，器官移植的大部分工作仅限于狗和人类受试者的研究。1，3，5，6然而，由于缺乏在缺血受体中的伴随实验，在这种高度异质性的群体中进行移植免疫的研究受到了阻碍。近交系之间的移植具有许多优点，包括更可重复的结果，更好的控制，和连续供应的isoblasts组织。器官移植是很难在较小的哺乳动物作为近交系，但是，除了一系列的肾脏移植在大鼠2，移植免疫的研究在很大程度上依赖于使用皮肤或可移植的肿瘤。这些系统都不是理想的研究早期免疫病理变化及其相互关系。在两种方法中发生的再血管化在游离皮肤移植中由于短暂但强烈的表皮细胞活性、增生和水肿而进一步复杂化。对同种异体移植物中这些变化的极好讨论
To date most of the work in organ transplantation has been confined to studies in dogs and human subjects. 1,3,5,6 Investigation of transplantation immunity in such highly heterogeneous groups has been hampered, however, by lack of companion experiments in isologous recipients. Transplantation between inbred strains has many advantages, including more reproducible results, better controls, and a continuous supply of isologous tissue. Organ transplantation is difficult in the smaller mammals available as inbred lines, however, and with the exception of a series of kidney transplants in the rat, 2 the study of transplantation immunity has depended heavily on use of skin or of transplantable tumors. Neither of these systems is ideal for investigation of early immunopathologic changes and their interrelations. The revascularization which occurs in both methods is further complicated in free skin-grafting by transient but intense epidermal cell activity, hyperplasia, and edema. An excellent discussion of these changes in isografts