Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice.
Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice.
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DOI：
10.1186/1710-1492-6-7
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发表时间：
2010-05-11
期刊：
影响因子：
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通讯作者：
Miller RL
中科院分区：
文献类型：
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作者：
Corson L;Zhu H;Quan C;Grunig G;Ballaney M;Jin X;Perera FP;Factor PH;Chen LC;Miller RL
多项研究表明，产前接触过敏原或空气污染可能会增加年幼后代发生过敏性免疫反应的风险。然而，产前环境暴露对成年后代的影响尚未得到充分研究。我们假设，产前接触烟曲霉 (A. fumigatus) 过敏原和柴油机尾气颗粒与成年后代 IgE 产生改变、气道炎症、气道高反应性 (AHR) 和气道重塑有关。通过气道途径对烟曲霉致敏并交配后，怀孕的 BALB/c 小鼠暴露于额外的烟曲霉和/或柴油机尾气颗粒。在 9-10 周大时，他们的后代受到烟曲霉的致敏和攻击。我们发现，在怀孕期间接触烟曲霉或柴油机尾气颗粒的小鼠的成年后代的 IgE 产量会减少。在怀孕期间接触烟曲霉和柴油机尾气颗粒的小鼠成年后代的气道嗜酸粒细胞增多症会减少。这些结果表明，在该模型中，妊娠期间过敏原和/或柴油的施用可能与保护成年后代免于发生全身和气道过敏性免疫反应有关。
Multiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However, the effects of prenatal environmental exposures on adult offspring have not been well-studied. We hypothesized that combined prenatal exposure to Aspergillus fumigatus (A. fumigatus) allergen and diesel exhaust particles will be associated with altered IgE production, airway inflammation, airway hyperreactivity (AHR), and airway remodeling of adult offspring. Following sensitization via the airway route to A. fumigatus and mating, pregnant BALB/c mice were exposed to additional A. fumigatus and/or diesel exhaust particles. At age 9-10 weeks, their offspring were sensitized and challenged with A. fumigatus. We found that adult offspring from mice that were exposed to A. fumigatus or diesel exhaust particles during pregnancy experienced decreases in IgE production. Adult offspring of mice that were exposed to both A. fumigatus and diesel exhaust particles during pregnancy experienced decreases in airway eosinophilia. These results suggest that, in this model, allergen and/or diesel administration during pregnancy may be associated with protection from developing systemic and airway allergic immune responses in the adult offspring.