Behavioral effects of estrogen receptor gene disruption in male mice
Behavioral effects of estrogen receptor gene disruption in male mice
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DOI：
10.1073/pnas.94.4.1476
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发表时间：
1997-02-18
影响因子：
11.1
通讯作者：
Pfaff, DW
中科院分区：
文献类型：
--
作者：
Ogawa, S;Lubahn, DB;Pfaff, DW
性腺类固醇激素调节大脑功能和行为的性别二态性发育。它们的核受体提供了将神经元中的分子事件与简单的哺乳动物本能行为联系起来的机会。我们通过使用转基因雌激素受体缺陷（ERKO）小鼠，确定了内源性雌激素激活雌激素受体（ER）在雄性典型行为发展中的作用。令人惊讶的是，尽管ERKO小鼠不育，但它们表现出正常的骑乘雌性的动机，但它们的性交次数较少，几乎没有射精，攻击性行为显着减少，ERKO雄性小鼠很少表现出雄性典型的攻击性攻击。此外，ER基因破坏使开放场行为去男性化，在大脑中，尽管功能性ER蛋白明显丧失，但雄激素依赖性系统似乎在ERKO小鼠中正常存在。总之，这些发现表明，除了简单的性行为外，发育过程中ER基因的表达在男性典型的攻击性和情绪行为的组织中发挥着重要作用。
Gonadal steroid hormones regulate sexually dimorphic development of brain functions and behaviors. Their nuclear receptors offer the opportunity to relate molecular events in neurons to simple instinctive mammalian behaviors, We have determined the role of estrogen receptor (ER) activation by endogenous estrogen in the development of male-typical behaviors by the use of transgenic estrogen-receptor-deficient (ERKO) mice. Surprisingly, in spite of the fact that they are infertile, ERKO mice showed normal motivation to mount females but they achieved less intromissions and virtually no ejaculations, Aggressive behaviors were dramatically reduced and male-typical offensive attacks were rarely displayed by ERKO males. Moreover, ER gene disruption demasculinized open-field behaviors, In the brain, despite the evident loss of functional ER protein, the androgen-dependent system appears to be normally present in ERKO mice, Together, these findings indicate that ER gene expression during development plays a major role in the organization of male-typical aggressive and emotional behaviors in addition to simple sexual behaviors.