Analysis of cardiorespiratory phase coupling and cardiovascular autonomic responses during food ingestion
Analysis of cardiorespiratory phase coupling and cardiovascular autonomic responses during food ingestion
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DOI：
10.1016/j.physbeh.2016.03.004
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发表时间：
2016-05-15
影响因子：
2.9
通讯作者：
Saitoh, Tadashi
中科院分区：
文献类型：
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作者：
Niizeki, Kyuichi;Saitoh, Tadashi
本研究分析了是否呼吸性窦性心律失常（RSA）的相位相干性（lambda）的改变，在健康的年轻受试者的食物摄入。经过5分钟的休息控制，13名健康志愿者被要求吃固体食物，并以自己的速度获得水，然后是5分钟的餐后状态。分别使用心电图、Finapres装置和电感体积描记法记录R-R间期（RRI）、心跳间血压（BP）和呼吸活动。通过连续血压测量的脉搏轮廓法计算每搏输出量，通过每搏输出量乘以心率获得心输出量（CO）。从RSA和呼吸的振荡信号中计算λ;此外，使用短时傅立叶变换计算心率变异性（HRV）的频域指数。分别分析了稳态3 min休息期（R）、摄食期（FOOD）、餐后前2 min和餐后3 min。我们还比较了不同日期使用相同方案咀嚼口香糖（GUM）和饮水（WATER）的反应。与R相比，在FOOD中观察到RRI缩短以及BP和CO增加，表明交感迷走神经平衡向交感神经激活的转变。在GUM条件下观察到类似的反应，但幅度较小，而在WATER条件下仅观察到RRI的短暂缩短。心率变异性指标没有显示任何显着的变化，响应于树胶和水，但交感迷走神经平衡转移有利于交感神经优势的食物。λ在所有条件下都降低。有一个显着的负相关性之间的lambda和交感迷走神经平衡的间接措施。这些结果表明，摄入食物诱导增强心脏交感神经活动和RSA的相位相干性可以提供一个敏感的措施，用于评估心脏自主曲线。(C)2016 Elsevier Inc. All rights reserved.
The present study analyzed whether the phase coherency (lambda) of respiratory sinus arrhythmia (RSA) is altered by food ingestion in healthy young subjects. After 5 min of resting control, 13 healthy volunteers were asked to eat a solid meal with access to water at their own pace, followed by 5 min of the postprandial state. The R-R interval (RRI), beat-to-beat blood pressure (BP), and respiratory activity were recorded using electrocardiography, a Finapres device, and inductance plethysmography, respectively. The stroke volume was calculated by the pulse-contour method from continuous BP measurement, and the cardiac output (CO) was obtained by multiplying the stroke volume by the heart rate. From the oscillatory signals of RSA and respiration, lambda was computed; additionally, frequency domain indexes of the heart rate variability (HRV) were calculated using a short-time Fourier transform. A steady-state 3-min resting period (R), food ingestion period (FOOD), and the first 2-min and the last 3-min of the post prandial period were analyzed separately. We also compared the responses to gum chewing (GUM) and water intake (WATER) using the same protocol on separate days. A shortening of RRI and increases in BP and CO were observed in FOOD compared to R, suggesting a shift of sympathovagal balance toward sympathetic activation. Similar responses but smaller magnitudes were observed in the GUM condition, whereas only transient shortening of RRI was observed in the WATER condition. The HRV indexes did not show any significant changes in response to GUM and WATER but sympathovagal balance was shifted in favor of sympathetic dominance in FOOD. lambda decreased during all of the conditions. There was a significant negative correlation between lambda and the indirect measure of sympathovagal balance. These results suggest that ingestion of food induces enhanced cardiac sympathetic activity and that a phase coherence of RSA could provide a sensitive measure for evaluating the cardiac autonomic profile. (C) 2016 Elsevier Inc. All rights reserved.