Increasing fluorous partition coefficients by solvent tuning.
Increasing fluorous partition coefficients by solvent tuning.
复制标题
DOI：
10.1021/ol051170p
复制
发表时间：
2005-07
期刊：
影响因子：
5.2
通讯作者：
Marvin S. Yu;D. Curran;T. Nagashima
中科院分区：
文献类型：
--
作者：
Marvin S. Yu;D. Curran;T. Nagashima
在以全氟烷烃为氟相的液-液分离中，氟组分分配系数低一直是一个长期存在的问题。非氟相和氟相的溶剂调节极大地增强了轻或极性氟分子在氟液相中的分配，而对非氟分子的分配系数影响最小。这些发现表明，基于液体的分离在氟两相催化、氟标记试剂、氟支持的低聚物合成和相关领域的范围扩大了。[反应：见正文]
Low partition coefficients of fluorous components have been a persistent problem in liquid-liquid separations using perfluoroalkanes as the fluorous phase. Solvent tuning of both the nonfluorous and the fluorous phase dramatically enhances the partitioning of light or polar fluorous molecules into the fluorous liquid phase, while minimally effecting partition coefficients of nonfluorous molecules. These findings suggest an expanded scope for liquid-based separations in fluorous biphasic catalysis, fluorous-tagged reagents, fluorous-supported oligomer synthesis, and related areas. [reaction: see text]