The association between cortisol, oxytocin, and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment
The association between cortisol, oxytocin, and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment
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DOI：
10.1016/j.psyneuen.2018.05.040
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发表时间：
2018-10-01
影响因子：
3.7
通讯作者：
Kolassa, Iris-Tatjana
中科院分区：
文献类型：
--
作者：
Boeck, Christina;Gumpp, Anja Maria;Kolassa, Iris-Tatjana
童年虐待（CM）与晚年患精神和躯体疾病的风险增加有关。然而，个人风险和复原力因素可能会影响心理压力的深层程度。我们假设与压力相关的激素皮质醇和与依恋相关的激素催产素构成生物因素，可能会减轻与 CM 相关的生物后遗症和长期健康结果。作为生物学结果，我们因此关注免疫细胞耗氧量，我们之前发现，随着 CM 经历的严重程度的增加，免疫细胞耗氧量也会增加。在由 49 名产后妇女组成的研究队列中，我们通过高分辨率呼吸测量法研究了 CM 经历、血清皮质醇和血浆催产素水平以及完整外周血单核细胞 (PBMC) 的细胞耗氧量之间的相互作用。回归分析显示，CM 经历的严重程度与皮质醇以及催产素对产后三个月 PBMC 细胞耗氧量之间存在显着的相互作用：因此，较高的皮质醇水平与基础线粒体呼吸和 ATP 周转相关的耗氧量增加有关，而在 CM 严重程度较高的个体中，与基础线粒体呼吸和 ATP 周转相关的耗氧量随着催产素水平的升高而减少。在没有或很少有 CM 经验的女性中没有发现这些关联。总之，结果表明，皮质醇和催产素可能与外周免疫细胞生物能谱中与 CM 相关的改变产生相反的影响。
Childhood maltreatment (CM) is associated with an increased risk for the development of psychiatric and somatic diseases in later life. Individual risk and resilience factors may, however, influence how deep psychological stress gets under the skin. We hypothesized that the stress-related hormone cortisol and the attachment-related hormone oxytocin constitute biological factors that might moderate the biological sequelae and long-term health outcomes associated with CM. As biological outcome, we thereby focused on immunocellular oxygen consumption, which we previously found to be increased with a higher severity of CM experiences. In a study cohort of N = 49 postpartum women, we investigated the interaction between CM experiences, serum cortisol and plasma oxytocin levels, and the cellular oxygen consumption of intact peripheral blood mononuclear cells (PBMC) by high-resolution respirometry. Regression analyses revealed a significant interaction between the severity of CM experiences and cortisol as well as oxytocin on cellular oxygen consumption of PBMC three months postpartum: higher cortisol levels were thereby associated with an increase in oxygen consumption related to basal mitochondrial respiration and ATP turnover, while oxygen consumption related to basal mitochondrial respiration and ATP turnover were reduced with higher oxytocin levels in individuals with higher CM severity. These associations were not seen among women with no or low CM experiences. Together, the results suggest that cortisol and oxytocin might be associated with opposite effects on CM-related alterations in the bioenergetic profile of peripheral immune cells.