Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization.
Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization.
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DOI：
10.1371/journal.pone.0174633
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Terai K
中科院分区：
文献类型：
--
作者：
Nagasawa-Masuda A;Terai K
血管退化是必不可少的去除多余的血管在形成一个有效的血管网络，可以运输氧气和营养物质到身体的每一个角落。然而，没有机制可以解释在发育过程中大血管是如何退化的。本研究以斑马鱼尾静脉丛（dCVP）背侧为研究对象，探讨了Yap/Taz在血管退化中的新作用。在退化过程中，内皮细胞内的血液循环激活了Yap/Taz。这导致Ctgf和肌动蛋白聚合的诱导。干扰Yap/Taz激活会减少Ctgf的产生，从而减少肌动蛋白聚合和血管退化。这些结果暗示了Yap/Taz在血管退化中的新作用。
Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress during development. Here we use the dorsal part of the caudal vein plexus (dCVP) in Zebrafish to investigate the mechanism of regression and discover a new role of Yap/Taz in vascular regression. During regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression. These results implicate a novel role of Yap/Taz in vascular regression.