The role of iodine in autoimmune thyroiditis.
The role of iodine in autoimmune thyroiditis.
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DOI：
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发表时间：
1997
影响因子：
1.3
通讯作者：
N. Rose;A. Saboori;L. Rasooly;C. Burek
中科院分区：
文献类型：
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作者：
N. Rose;A. Saboori;L. Rasooly;C. Burek
像大多数癌症一样，自身免疫性疾病通常是由于一些遗传特征与环境触发因素的相互作用造成的。自身免疫性甲状腺炎是器官特异性自身免疫性疾病的一种模型，与碘作为一种沉淀环境因素有关。慢性甲状腺炎患者的T细胞对正常人甲状腺球蛋白有反应而增殖，但不能与非碘甲状腺球蛋白反应。使用一种选定的单抗，我们能够确定含有碘化甲状腺原氨酸的甲状腺球蛋白上的结合部位。亲和力最强的是四碘甲腺原氨酸，结合作用依赖于碘的数目和位置。我们还研究了一种近交系小鼠，NOD-H_2H4，它会自发地患上甲状腺炎。通过在饮用水中添加碘，以剂量依赖的方式加速了疾病的发生。疾病的发生在常规小鼠中比在无特定病原体的小鼠中更严重，并与T细胞增殖和抗甲状腺球蛋白IgG2b抗体有关。
Like most cancers, autoimmune diseases generally are due to the interaction of a number of genetic traits with an environmental trigger. Autoimmune thyroiditis, a model of organ-specific autoimmune disease, is associated with iodine as a precipitating environmental factor. T cells from patients with chronic thyroiditis proliferate in response to normal human thyroglobulin, but fail to react with non-iodinated thyroglobulin. Using a selected monoclonal antibody, we were able to identify a binding site on thyroglobulin containing iodinated thyronine. The greatest affinity was for tetraiodothyronine and binding depended upon the number as well as the positions of iodines. We have also studied an inbred strain of mice, NOD-H2h4, that developed thyroiditis spontaneously. The onset of disease was hastened in a dose-dependent manner by adding iodine to the drinking water. The occurrence of disease was greater in conventional than in specific pathogen-free mice and correlated with T-cell proliferation and IgG2b antibody to thyroglobulin.